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The aim of this study was to assess the addition of aliskiren to other antihypertensive drug treatment for arterial stiffness and endothelial function. Thirty uncontrolled hypertensive patients (mean age, 60.4\u00b112.2 years), without any other cardiovascular risk factors, were enrolled. Augmentation index (<jats:styled-content style=\"fixed-case\">AI<\/jats:styled-content>x) and carotid\u2010femoral pulse wave velocity (cf<jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content>) by applanation tonometry and reactive hyperemia peripheral arterial tonometry (<jats:styled-content style=\"fixed-case\">RH PAT)<\/jats:styled-content>index using peripheral arterious tonometry at baseline and after 6\u00a0months of aliskiren titrated to 300\u00a0mg once a day was evaluated. The addition of aliskiren had no effect on values of central<jats:styled-content style=\"fixed-case\">AI<\/jats:styled-content>x (33.26\u00b110.74% vs 28.86\u00b110.74%;<jats:italic>P<\/jats:italic>=.36) but did significantly improve values of cf<jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content>(9.36\u00b12.65\u00a0m\/s vs 8.72\u00b12.48\u00a0m\/s;<jats:italic>P<\/jats:italic>=.04) and<jats:styled-content style=\"fixed-case\">RH PAT<\/jats:styled-content>index (1.64\u00b10.57 vs 1.75\u00b10.45;<jats:italic>P<\/jats:italic>=.05). In addition to improving systolic and diastolic blood pressure, the addition of aliskiren to concomitant antihypertensive drugs in uncontrolled hypertensive patients may be effective in improving aortic stiffness and endothelial function. These results encourage further studies to evaluate the use of aliskiren for cardiovascular prevention.<\/jats:p>","DOI":"10.1111\/jch.12262","type":"journal-article","created":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T09:13:42Z","timestamp":1392801222000},"page":"202-206","source":"Crossref","is-referenced-by-count":18,"title":["Role of Aliskiren on Arterial Stiffness and Endothelial Function in Patients With Primary Hypertension"],"prefix":"10.1111","volume":"16","author":[{"given":"Ivano","family":"Bonadei","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical, Radiological Sciences and Public Health Specialties University of Study of Brescia Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Vizzardi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical, Radiological Sciences and Public Health Specialties University of Study of Brescia Brescia 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