{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T06:46:27Z","timestamp":1770533187599,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T00:00:00Z","timestamp":1392854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>Imaging of the kidney using blood oxygen level dependent (BOLD) magnetic resonance imaging (MRI) presents a major opportunity to examine differences in tissue oxygenation within the cortex and medulla applicable to human disease. The aim of this study was to evaluate BOLD signals before and after treatment with RAS inhibitors in hypertensive chronic kidney disease (CKD) patients. Ten patients with stable CKD and 5 healthy volunteers were included. Five CKD patients were subjected to BOLD MRI scan before and after chronic treatment with 300 mg\/day aliskiren for at least 6 weeks. Five other CKD patients received BOLD MRI before and 1 hour after acute treatment with 50 mg captopril. A group of healthy volunteers (n=5) was scanned before and 1 hour after acute treatment with 50 mg captopril. The 10 patients had a mean age of 61\u00b117 years; eGFR of 30\u00b111 mL\/min per 1.73 m<jats:sup>2<\/jats:sup>. Office systolic and diastolic blood pressures when on a RAS inhibito, were 130\u00b110 and 86\u00b15 mmHg in CKD patients. Control subjects had normal kidney function and were not on any medication. In untreated condition, systolic and diastolic arterial blood pressure elevated, 145\u00b16 and 95\u00b14 mmHg, respectively. After chronic treatment with aliskiren, arterial blood pressure decreased in all patients in this group, 127\u00b13 mmHg and 77\u00b13 mmHg. After acute treatment with captopril arterial blood pressure reduced to 125\u00b14 and 71\u00b18 mmHg. Tissue intensity signal (T2*) was increased in medulla after chronic treatment from 29\u00b16 to 34\u00b16 and after acute treatment with captopril from 34\u00b19 to 38\u00b111 in CKD patients. In addition, T2* ratio between cortex and medulla decreased in CKD patients after chronic treatment and acute treatment. This ratio remained stable in healthy volunteers before and after treatment with captopril 1.62\u00b10.1 and 1.65\u00b10.1, respectively. This study shows for the first time that RAS inhibitors change BOLD signal in CKD patients. Importantly, in healthy volunteers, a RAS inhibitor had no such effect. Further investigation is required.<\/jats:p>","DOI":"10.1111\/jch.12263","type":"journal-article","created":{"date-parts":[[2014,2,21]],"date-time":"2014-02-21T01:21:00Z","timestamp":1392945660000},"page":"214-218","source":"Crossref","is-referenced-by-count":25,"title":["Inhibition of the Renin\u2010Angiotensin System Affects Kidney Tissue Oxygenation Evaluated by <scp>Magnetic Resonance Imaging<\/scp> in Patients With Chronic Kidney Disease"],"prefix":"10.1111","volume":"16","author":[{"given":"Laima","family":"Siddiqi","sequence":"first","affiliation":[{"name":"Department of Nephrology and Hypertension University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Hoogduin","sequence":"additional","affiliation":[{"name":"Department of Radiology, Radiotherapy and Nuclear Medical Science University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Freddy","family":"Visser","sequence":"additional","affiliation":[{"name":"Department of Radiology, Radiotherapy and Nuclear Medical Science University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Leiner","sequence":"additional","affiliation":[{"name":"Department of Radiology, Radiotherapy and Nuclear Medical Science University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem P.","family":"Mali","sequence":"additional","affiliation":[{"name":"Department of Radiology, Radiotherapy and Nuclear Medical Science University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Blankestijn","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32832b521b"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90757.2008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1998.274.5.F940"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb16081.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702718"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000220109.98142.a3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.481"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000125614.35046.10"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005050522"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000071289"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2012(07)10"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007040420"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2009.05.044"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1378"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328364ca4c"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjch.12263","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjch.12263","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.12263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T21:01:21Z","timestamp":1695502881000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.12263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,20]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/jch.12263"],"URL":"https:\/\/doi.org\/10.1111\/jch.12263","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,20]]}}}