{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:22:52Z","timestamp":1790630572047,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T00:00:00Z","timestamp":1392768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30871054"],"award-info":[{"award-number":["30871054"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Twelfth Five-Year Project","award":["2011BAI11B04"],"award-info":[{"award-number":["2011BAI11B04"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2014,3]]},"abstract":"The genetic susceptibility to orthostatic blood pressure dysregulation remains poorly understood. The association between polymorphisms of beta\u2010adrenergic receptor (\u03b2\u2010AR<\/jats:italic><\/jats:styled-content>) genes and orthostatic blood pressure dysregulation in hypertensive patients was investigated. Two polymorphisms of\u03b21<\/jats:sub>\u2010AR<\/jats:italic><\/jats:styled-content>(A<\/jats:styled-content>rg389\/G<\/jats:styled-content>ly) and\u03b22<\/jats:sub>\u2010AR<\/jats:italic><\/jats:styled-content>(A<\/jats:styled-content>rg16\/G<\/jats:styled-content>ly) were genotyped in untreated hypertensive patients and normotensive patients. In patients with untreated hypertension, the frequency of\u03b21<\/jats:sub>\u2010AR<\/jats:italic>G<\/jats:styled-content>ly389 homozygote was significantly higher in patients with orthostatic hypotension (OH<\/jats:styled-content>) (P<\/jats:italic><.0001) and lower in patients with orthostatic hypertension (OHT<\/jats:styled-content>) (P<\/jats:italic>=.002) as compared with patients with orthostatic normotension (ONT<\/jats:styled-content>) even afterB<\/jats:styled-content>onferroni correction. After analysis by sex and adjustment for conventional risk factors, the\u03b21<\/jats:sub>\u2010AR<\/jats:italic><\/jats:styled-content>Gly389 homozygote conferred about a 3\u2010fold risk ofOH<\/jats:styled-content>and independently predicted a 6.5\u00a0mm Hg greater orthostaticSBP<\/jats:styled-content>decrease (GG<\/jats:styled-content>\u22128.9\u00b113\u00a0mm Hg vsCC<\/jats:styled-content>+CG<\/jats:styled-content>\u22122.4\u00b112\u00a0mm Hg,P<<\/jats:italic>.001) only in female hypertensive patients. The association of\u03b22<\/jats:sub>\u2010AR<\/jats:italic>A<\/jats:styled-content>rg16\/G<\/jats:styled-content>ly withOH<\/jats:styled-content>was not significant after adjustment for conventional risk factors. In normotensive patients, no association was identified between these two polymorphisms andOHT<\/jats:styled-content>orOH<\/jats:styled-content>. These results indicated that the\u03b21<\/jats:sub>\u2010AR<\/jats:italic>A<\/jats:styled-content>rg389\/G<\/jats:styled-content>ly polymorphism may be associated with increased risk ofOH<\/jats:styled-content>in female hypertensive patients.<\/jats:p>","DOI":"10.1111\/jch.12272","type":"journal-article","created":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T11:53:08Z","timestamp":1392810788000},"page":"207-213","source":"Crossref","is-referenced-by-count":12,"title":["Orthostatic Blood Pressure Dysregulation and Polymorphisms of \u03b2\u2010Adrenergic Receptor Genes in Hypertensive Patients"],"prefix":"10.1111","volume":"16","author":[{"given":"Ying","family":"Gao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease Department of Cardiology Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences Peking Union Medical College Beijing 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