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Autonomic nervous system imbalance resulting in overactivity of the sympathetic nervous system is integral to the development of hypertension and ultimately the development of hypertensive heart disease. Although the results with renal sympathetic denervation so far have been encouraging, optimism has recently been tempered with the broadcast alert from <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>edtronic, the sponsor of <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ymplicity <jats:styled-content style=\"fixed-case\">HTN<\/jats:styled-content>\u20103, that the trial did not meet its primary efficacy endpoint. The principal focus of this article is to review the developments in renal sympathetic denervation for the treatment of resistant hypertension.<\/jats:p>","DOI":"10.1111\/jch.12285","type":"journal-article","created":{"date-parts":[[2014,3,21]],"date-time":"2014-03-21T07:56:41Z","timestamp":1395388601000},"page":"331-341","source":"Crossref","is-referenced-by-count":7,"title":["Renal Sympathetic Denervation for Blood Pressure Control: A Review of the Current Evidence and Ongoing Studies"],"prefix":"10.1111","volume":"16","author":[{"given":"Thomas M.","family":"Todoran","sequence":"first","affiliation":[{"name":"Division of Cardiology Medical University of South Carolina Charleston SC"},{"name":"Ralph H. 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