{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:58:08Z","timestamp":1784329088984,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,5,27]],"date-time":"2014-05-27T00:00:00Z","timestamp":1401148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p>This retrospective review examined all primary aldosteronism (<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>) adrenal vein sampling (<jats:styled-content style=\"fixed-case\">AVS<\/jats:styled-content>), diagnoses, and outcomes from an endocrine hypertension unit where confirmatory testing was abandoned in 2005 to determine the potential rate of false\u2010positive diagnoses. Patients with outcome\u2010verified <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> (surgical patients) were compared with patients with high\u2010probability <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> (nonsurgical but high aldosterone\u2010renin ratio, imaging abnormalities, and\/or hypokalemia) or possible <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> (nonsurgical, no features besides mild elevation of aldosterone\u2010renin ratio, a potential false diagnosis of <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>). Of 83 patients, 58% had unilateral <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> and 42% had bilateral aldosteronism. Less than 3% of the cohort showed bilateral aldosteronism without hypokalemia or <jats:styled-content style=\"fixed-case\">computed tomographic<\/jats:styled-content> findings, potentially representing the false\u2010positive <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> diagnosis rate with omission of confirmatory tests in this population. In a hypertension referral unit enriched in high\u2010probability <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> cases and where high <jats:styled-content style=\"fixed-case\">AVS<\/jats:styled-content> success is achieved, omission of a <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> confirmatory test yields a high rate of surgical diagnosis with few potential false\u2010positive diagnoses.<\/jats:p>","DOI":"10.1111\/jch.12342","type":"journal-article","created":{"date-parts":[[2014,5,27]],"date-time":"2014-05-27T06:35:01Z","timestamp":1401172501000},"page":"488-496","source":"Crossref","is-referenced-by-count":38,"title":["High\u2010Probability Features of Primary Aldosteronism May Obviate the Need for Confirmatory Testing Without Increasing False\u2010Positive Diagnoses"],"prefix":"10.1111","volume":"16","author":[{"given":"Gregory A.","family":"Kline","sequence":"first","affiliation":[{"name":"Division of Endocrinology Department of Medicine University of Calgary Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice L.","family":"Pasieka","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Calgary Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Harvey","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Calgary Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benny","family":"So","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Calgary Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val C.","family":"Dias","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology University of Calgary Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.KR-105"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.8.2854"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001013"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200311000-00025"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.095448"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2007.33"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-004-7496-z"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-011-1221-5"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1299681"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc3000"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0104"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1304661"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2504"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1314786"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1470320310390405"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0078"},{"key":"e_1_2_9_18_1","volume-title":"Evidence\u2010Based Medicine; 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