{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:51:50Z","timestamp":1791118310269,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T00:00:00Z","timestamp":1406073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health grant","doi-asserted-by":"crossref","award":["R01HL094784-05"],"award-info":[{"award-number":["R01HL094784-05"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>Cardiotrophin\u20101 (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\u20101) is a member of the interleukin 6 cytokine superfamily. Plasma <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\u20101 levels have been associated with heart failure and hypertension in small independent studies. Whether plasma <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\u20101 levels are associated with progression of hypertensive heart disease is poorly understood. The authors carried out a meta\u2010analysis using published studies and electronic databases. Relevant data were extracted using standardized algorithms. Additional data were obtained directly from investigators when indicated. A total of 18 studies were included that reported on association between <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\u20101 level and hypertension (n=8), cardiac hypertrophy (n=9), and heart failure (<jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>) (n=10). The serum levels of <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\u20101 were significantly higher in patients with hypertension (standard mean difference [<jats:styled-content style=\"fixed-case\">SMD<\/jats:styled-content>], 0.85; 95% <jats:styled-content style=\"fixed-case\">confidence interval [CI],<\/jats:styled-content> 0.64\u20131.06\u00a0fmol\/mL), left ventricular hypertrophy (<jats:styled-content style=\"fixed-case\">SMD,<\/jats:styled-content> 0.88; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.60\u20131.17\u00a0fmol\/mL), or <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">SMD<\/jats:styled-content>, 0.66; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.51\u20130.80\u00a0fmol\/mL) compared with controls. Subgroup analysis revealed <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\u20101 levels to be highest in patients with hypertension\u2010induced hypertrophy with <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>, followed by patients with hypertension\u2010induced <jats:styled-content style=\"fixed-case\">left ventricular hypertrophy<\/jats:styled-content> without <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">SMD,<\/jats:styled-content> 0.52; 95% <jats:styled-content style=\"fixed-case\">CI,<\/jats:styled-content> 0.30\u20130.75\u00a0fmol\/mL), patients with hypertension without left ventricular hypertrophy (<jats:styled-content style=\"fixed-case\">SMD,<\/jats:styled-content> 0.67; 95% <jats:styled-content style=\"fixed-case\">CI,<\/jats:styled-content> 0.46\u20130.88\u00a0fmol\/mL) as compared with normotensive patients (<jats:styled-content style=\"fixed-case\">SMD,<\/jats:styled-content> 0.74; 95% <jats:styled-content style=\"fixed-case\">CI,<\/jats:styled-content> 10.45\u20131.04\u00a0fmol\/mL). Increased plasma <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\u20101 levels are associated with risk for HF in hypertensive patients. <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\u20101 may serve as a novel biomarker in determining prognosis in hypertensive patients.<\/jats:p>","DOI":"10.1111\/jch.12376","type":"journal-article","created":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T05:23:13Z","timestamp":1406092993000},"page":"686-692","source":"Crossref","is-referenced-by-count":23,"title":["Plasma Cardiotrophin\u20101 Levels are Associated With Hypertensive Heart Disease: A Meta\u2010Analysis"],"prefix":"10.1111","volume":"16","author":[{"given":"Kangxing","family":"Song","sequence":"first","affiliation":[{"name":"Yale Cardiovascular Research Center Department of Internal Medicine Yale University School of Medicine New Haven CT"},{"name":"The Cardiology Department Chinese Peoples\u2019 Liberation Army General Hospital Beijing 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