{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:24:08Z","timestamp":1773213848762,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T00:00:00Z","timestamp":1407369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck & Co., Inc.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>Data from four clinical trials compared reductions in systolic blood pressure (<jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>) and diastolic blood pressure (<jats:styled-content style=\"fixed-case\">DBP<\/jats:styled-content>) among patients treated with amlodipine\/losartan 5\/50\u00a0mg vs 5\/100\u00a0mg and amlodipine\/losartan 5\/50\u00a0mg vs amlodipine 5\u00a0mg and 10\u00a0mg. Response rate was assessed as reduction in <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">DBP<\/jats:styled-content> (&gt;20\/10 mm Hg) and proportion of patients achieving <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content> &lt;140 mm Hg or <jats:styled-content style=\"fixed-case\">DBP<\/jats:styled-content> &lt;90 mm Hg. Patients were grouped into quartiles based on baseline <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DBP<\/jats:styled-content>. Mean <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DBP<\/jats:styled-content> were reduced in amlodipine\/losartan 5\/50\u00a0mg (n=182) and amlodipine\/losartan 5\/100\u00a0mg (n=95) users across all baseline quartiles. Patients using amlodipine\/losartan 5\/50\u00a0mg had significantly greater <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DBP<\/jats:styled-content> reductions vs amlodipine 5\u00a0mg (<jats:italic>P<\/jats:italic>=.001 and <jats:italic>P<\/jats:italic>=.02, respectively). Amlodipine\/losartan 5\/50\u00a0mg users had significantly greater <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content> reduction vs amlodipine 10\u00a0mg (<jats:styled-content style=\"fixed-case\">SBP <\/jats:styled-content><jats:italic>P<\/jats:italic>=.02; <jats:styled-content style=\"fixed-case\">DBP <\/jats:styled-content><jats:italic>P<\/jats:italic>=<jats:styled-content style=\"fixed-case\">not significant<\/jats:styled-content>). The odds of responding to therapy were significantly greater with amlodipine\/losartan 5\/50\u00a0mg vs amlodipine 5\u00a0mg (<jats:styled-content style=\"fixed-case\">odds ratio,<\/jats:styled-content> 5.33; 95% <jats:styled-content style=\"fixed-case\">confidence interval,<\/jats:styled-content> 1.42\u201325.5) and were similar vs amlodipine 10\u00a0mg (<jats:styled-content style=\"fixed-case\">odds ratio,<\/jats:styled-content> 0.67; 95% <jats:styled-content style=\"fixed-case\">confidence interval,<\/jats:styled-content> 0.017\u20139.51). These results support the use of combination therapy early in the treatment of hypertension.<\/jats:p>","DOI":"10.1111\/jch.12390","type":"journal-article","created":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T09:43:45Z","timestamp":1407404625000},"page":"671-677","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of Blood Pressure Reduction Response and Responder Characteristics to Fixed\u2010Dose Combination Treatment of Amlodipine and Losartan: A Post Hoc Analysis of Pooled Clinical Trials"],"prefix":"10.1111","volume":"16","author":[{"given":"Sreevalsa","family":"Unniachan","sequence":"first","affiliation":[{"name":"Merck &amp; Co. Inc. Whitehouse Station NJ"},{"name":"Rutgers School of Public Health Piscataway NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Wu","sequence":"additional","affiliation":[{"name":"Merck &amp; Co. Inc. 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