{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:03:28Z","timestamp":1791216208386,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,9,19]],"date-time":"2014-09-19T00:00:00Z","timestamp":1411084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>Resistant hypertension (<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>) is understudied and its reported prevalence varies with study populations. The authors sought to determine its prevalence and association with certain comorbid conditions in a <jats:styled-content style=\"fixed-case\">Veterans Affairs<\/jats:styled-content> population. This cross\u2010sectional study utilized demographic and clinical data from 17,466 patients. Chi\u2010square or <jats:italic>t<\/jats:italic> test was used for comparing groups with and without <jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>. Multivariate logistic regression analysis was used to determine independent associations. Overall, the prevalence of <jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> was 9%, and 13% of all hypertensive patients met criteria for RH. After adjusting for confounding variables, <jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> was significantly associated with older age (odds ratio [<jats:styled-content style=\"fixed-case\">OR],<\/jats:styled-content> 1.007), higher <jats:styled-content style=\"fixed-case\">body mass index<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR,<\/jats:styled-content> 1.04), Framingham score (<jats:styled-content style=\"fixed-case\">OR,<\/jats:styled-content> 1.14), and coexisting <jats:styled-content style=\"fixed-case\">coronary artery disease<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> cerebrovascular accident<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">transient ischemic attack<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> peripheral vascular disease<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> congestive heart failure<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> chronic kidney disease<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> diabetes mellitus<\/jats:styled-content>, erectile dysfunction, and metabolic syndrome (<jats:styled-content style=\"fixed-case\">OR,<\/jats:styled-content> 1.3, 1.32, 1.29, 2.88, 2.13, 1.2, 1.12, and 1.2, respectively; all <jats:italic>P<\/jats:italic>&lt;.05). Our results indicate a complex interplay of certain comorbid conditions among patients with <jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> and suggest the need for multifaceted interventions in this high\u2010risk population to prevent cardiovascular events.<\/jats:p>","DOI":"10.1111\/jch.12410","type":"journal-article","created":{"date-parts":[[2014,9,19]],"date-time":"2014-09-19T12:25:08Z","timestamp":1411129508000},"page":"741-745","source":"Crossref","is-referenced-by-count":33,"title":["Resistant Hypertension and Associated Comorbidities in a <scp>Veterans Affairs<\/scp> Population"],"prefix":"10.1111","volume":"16","author":[{"given":"Tushar","family":"Acharya","sequence":"first","affiliation":[{"name":"Primary Care Service VA Central California Health Care System Fresno CA"},{"name":"Department of Medicine University of California San Francisco\u2010Fresno Medical Education Program Fresno CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Tringali","sequence":"additional","affiliation":[{"name":"Primary Care Service VA Central California Health Care System Fresno CA"},{"name":"Department of Medicine University of California San Francisco\u2010Fresno Medical Education Program Fresno CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manmeet","family":"Singh","sequence":"additional","affiliation":[{"name":"Primary Care Service VA Central California Health Care System Fresno CA"},{"name":"Department of Medicine University of California San Francisco\u2010Fresno Medical Education Program Fresno CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Huang","sequence":"additional","affiliation":[{"name":"Primary Care Service VA Central California Health Care System Fresno CA"},{"name":"Department of Medicine University of California San Francisco\u2010Fresno Medical Education Program Fresno CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.06.043"},{"key":"e_1_2_9_3_1","unstructured":"World Health Organization. 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