{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:25:06Z","timestamp":1788279906827,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,9,29]],"date-time":"2014-09-29T00:00:00Z","timestamp":1411948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>This study assessed the urinary albumin\/creatinine ratio (<jats:styled-content style=\"fixed-case\">ACR<\/jats:styled-content>) and uric acid metabolism in 70 hypertensive patients with chronic kidney disease in whom urinary <jats:styled-content style=\"fixed-case\">ACR<\/jats:styled-content> had remained \u226530\u00a0mg\/g under the treatment of the L\u2010type calcium channel blocker amlodipine. Three months after switching to the N\/L\u2010type calcium channel blocker cilnidipine, blood pressure (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) did not change; however, urinary <jats:styled-content style=\"fixed-case\">ACR<\/jats:styled-content> significantly decreased with cilnidipine. Serum uric acid levels showed no significant change. In cases where uric acid production had been high (urinary uric acid\/creatinine ratio \u22650.5), the urinary uric acid\/creatinine ratio decreased significantly after cilnidipine treatment, suggesting that cilnidipine can suppress excessive uric acid formation. These results suggest that switching from amlodipine to cilnidipine results in a significant reduction in urinary <jats:styled-content style=\"fixed-case\">ACR<\/jats:styled-content> as well as significant reduction in uric acid production. 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