{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:08:32Z","timestamp":1789142912674,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,5]],"date-time":"2014-12-05T00:00:00Z","timestamp":1417737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Science and Technology","award":["99-2314-B-182A-106-MY3"],"award-info":[{"award-number":["99-2314-B-182A-106-MY3"]}]},{"name":"Ministry of Science and Technology","award":["102-2314-B-182A-060-MY2"],"award-info":[{"award-number":["102-2314-B-182A-060-MY2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>This retrospective claims database analysis compared two strategies of hypertension treatment in outpatient, emergency, and inpatient departments: a fixed\u2010dose combination (<jats:styled-content style=\"fixed-case\">FDC<\/jats:styled-content>) of amlodipine\/valsartan vs free combinations of angiotensin receptor blockers (<jats:styled-content style=\"fixed-case\">ARB<\/jats:styled-content>s) and calcium channel blockers (<jats:styled-content style=\"fixed-case\">CCB<\/jats:styled-content>s) (<jats:styled-content style=\"fixed-case\">ARB<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">CCB<\/jats:styled-content> group). After a mean follow\u2010up of 15.2\u00a0months, the <jats:styled-content style=\"fixed-case\">FDC<\/jats:styled-content> group had significantly lower total healthcare costs (<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> $1844 vs <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> $2158; <jats:italic>P<\/jats:italic>&lt;.001) and hospitalization rates (14.57% vs 18.43%; <jats:italic>P<\/jats:italic>&lt;.001), a higher proportion of days covered (80.35% vs 72.57%; <jats:italic>P<\/jats:italic>&lt;.001), and better persistence (266 vs 225\u00a0days; <jats:italic>P<\/jats:italic>&lt;.001) compared with the <jats:styled-content style=\"fixed-case\">ARB<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">CCB<\/jats:styled-content> group. The <jats:styled-content style=\"fixed-case\">FDC<\/jats:styled-content> group also had a better major adverse cardiovascular event (<jats:styled-content style=\"fixed-case\">MACE<\/jats:styled-content>)\u2013free survival (hazard ratio, 0.83; 95% confidence interval, 0.73\u20130.94; <jats:italic>P<\/jats:italic>=.003) and decreased rates of heart failure (2.12% vs 3.26%; <jats:italic>P<\/jats:italic>&lt;.001), malignant dysrhythmia (0.18% vs 0.42%; <jats:italic>P<\/jats:italic>=.021), and percutaneous coronary intervention (0.76% vs 1.26%; <jats:italic>P<\/jats:italic>=.015). Compared with free combinations of <jats:styled-content style=\"fixed-case\">ARB<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">CCB<\/jats:styled-content>, an <jats:styled-content style=\"fixed-case\">FDC<\/jats:styled-content> of amlodipine\/valsartan improved <jats:styled-content style=\"fixed-case\">MACE<\/jats:styled-content>\u2010free survival and medication compliance and decreased total healthcare costs and hospitalization rates in hypertensive patients.<\/jats:p>","DOI":"10.1111\/jch.12449","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T00:28:22Z","timestamp":1418084902000},"page":"51-58","source":"Crossref","is-referenced-by-count":26,"title":["Clinical Outcomes and Healthcare Costs in Hypertensive Patients Treated With a Fixed\u2010Dose Combination of Amlodipine\/Valsartan"],"prefix":"10.1111","volume":"17","author":[{"given":"Ying\u2010Chang","family":"Tung","sequence":"first","affiliation":[{"name":"Department of 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