{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T07:07:17Z","timestamp":1750662437123},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,12,24]],"date-time":"2014-12-24T00:00:00Z","timestamp":1419379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Daiichi-Sankyo Europe"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>Ambulatory blood pressure (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) and central systolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">cSBP<\/jats:styled-content>) are superior to brachial office <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> measurements in predicting cardiovascular end organ damage. The authors aimed to analyze the effect of olmesartan 80\u00a0mg (<jats:styled-content style=\"fixed-case\">OLM<\/jats:styled-content> 80) vs 20\u00a0mg (<jats:styled-content style=\"fixed-case\">OLM<\/jats:styled-content> 20) vs amlodipine 5\u00a0mg (<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content> 5) on central hemodymamics and ambulatory <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> in patients with metabolic syndrome (MetS).In a double\u2010blind, three\u2010phase crossover study comprising 69 untreated patients with MetS defined by the Third Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults guidelines, the effects of <jats:styled-content style=\"fixed-case\">OLM<\/jats:styled-content> 80 on central hemodynamics (<jats:styled-content style=\"fixed-case\">cSBP<\/jats:styled-content>), central pulse pressure), pulse wave velocity (<jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content>), and 24\u2010hour ambulatory <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> were compared with <jats:styled-content style=\"fixed-case\">OLM<\/jats:styled-content> 20 and <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content> 5, given for 6 weeks each. In 69 patients (47 men, 22 women) (51.5\u00b19.75\u00a0years), reduction in <jats:styled-content style=\"fixed-case\">cSBP<\/jats:styled-content> was the highest with <jats:styled-content style=\"fixed-case\">OLM<\/jats:styled-content> 80 and significantly greater than the reduction with <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content> 5 (\u221214.1\u00a0mm Hg vs \u22129.7\u00a0mm Hg, <jats:italic>P<\/jats:italic>=.0117). All three substances significantly reduced 24\u2010hour ambulatory systolic (OLM 80 and OLM 20 P&lt;.0001; AML 5 P=.0105). BP and 24\u2010hour diastolic BP (OLM 80 and OLM 20 P&lt;.0001; AML 5 P=.0126). <jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content> was significantly reduced by <jats:styled-content style=\"fixed-case\">OLM<\/jats:styled-content> 80 (\u22120.58\u00a0m\/s, <jats:italic>P<\/jats:italic>=.0088) and by <jats:styled-content style=\"fixed-case\">OLM<\/jats:styled-content> 20 (\u22120.48\u00a0m\/s, <jats:italic>P<\/jats:italic>=.0362) but not by <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content> 5 (\u22120.28\u00a0m\/s, <jats:italic>P<\/jats:italic>=.2065). For <jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content>, no significant differences were detected between the three groups. <jats:styled-content style=\"fixed-case\">OLM<\/jats:styled-content> significantly improves arterial stiffness as demonstrated by the reduction in <jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content> and in <jats:styled-content style=\"fixed-case\">cSBP<\/jats:styled-content>. In addition, 24\u2010hour ambulatory <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> was reduced to a greater extent with <jats:styled-content style=\"fixed-case\">OLM<\/jats:styled-content> 80 than with AML 5.<\/jats:p>","DOI":"10.1111\/jch.12458","type":"journal-article","created":{"date-parts":[[2014,12,24]],"date-time":"2014-12-24T06:05:18Z","timestamp":1419401118000},"page":"98-104","source":"Crossref","is-referenced-by-count":7,"title":["Olmesartan Improves Pulse Wave Velocity and Lowers Central Systolic Blood Pressure and Ambulatory Blood Pressure in Patients With Metabolic Syndrome"],"prefix":"10.1111","volume":"17","author":[{"given":"Ulrike","family":"Raff","sequence":"first","affiliation":[{"name":"Department of Nephrology and Hypertension University of Erlangen\u2010N\u00fcrnberg Erlangen\u2010N\u00fcrnberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension University of Erlangen\u2010N\u00fcrnberg Erlangen\u2010N\u00fcrnberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Ott","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension University of Erlangen\u2010N\u00fcrnberg Erlangen\u2010N\u00fcrnberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus P.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension University of Erlangen\u2010N\u00fcrnberg Erlangen\u2010N\u00fcrnberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland E.","family":"Schmieder","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension University of 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