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The aim of this meta\u2010analysis was to assess the efficacy and safety of this combination regarding the following endpoints: all\u2010cause and cardiovascular mortality, myocardial infarction, and stroke. Four studies with a total of 30,791 of patients met the inclusion criteria. The combination <jats:styled-content style=\"fixed-case\">CCB<\/jats:styled-content>\/thiazide (\u2010like) diuretic was associated with a significant risk reduction for myocardial infarction (risk ratio [<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>], 0.83; 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>], 0.73\u20130.95) and stroke (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>, 0.77; <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.64\u20130.92) compared with other combinations, whereas it was similarly effective compared with other combinations in reducing the risk of all\u2010cause (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>, 0.89; <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.75\u20131.06) and cardiovascular (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>, 0.89; <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.71\u20131.10) mortality. Elderly patients with isolated systolic hypertension may particularly benefit from such a combination, since both drug classes have been shown to confer cerebrovascular protection.<\/jats:p>","DOI":"10.1111\/jch.12462","type":"journal-article","created":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T06:55:21Z","timestamp":1420440921000},"page":"193-199","source":"Crossref","is-referenced-by-count":32,"title":["Efficacy and Safety of Calcium Channel Blocker\/Diuretics Combination Therapy in Hypertensive Patients: A Meta\u2010Analysis"],"prefix":"10.1111","volume":"17","author":[{"given":"Stefano F.","family":"Rimoldi","sequence":"first","affiliation":[{"name":"Department of Cardiology and Clinical Research University Hospital Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz H.","family":"Messerli","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Clinical Research University Hospital Bern 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