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The aldosterone to renin ratio (ARR) was measured without adjustment of antihypertensive medications, with further workup as appropriate. Two groups were defined: patients with surgically \u201cconfirmed PA\u201d (n=58) and patients with \u201chigh\u2010probability PA\u201d (n=59), defined as having any of the following: computed tomography\u2013confirmed adrenal adenoma plus lateralizing adrenal vein sampling (AVS) without surgery, high ARR and hypokalemia but nonlateralizing AVS, or ARR more than four times the upper limit of normal. The PRA 95th percentile was 1.0\u00a0ng\/mL\/h. All outliers had hypokalemia and two had adrenal adenomas. There was no difference between the confirmed and high probability groups. In the absence of highly suspicious clinical features, patients with unadjusted PRA &gt;1.0\u00a0ng\/mL\/h do not warrant further investigation for PA.<\/jats:p>","DOI":"10.1111\/jch.12523","type":"journal-article","created":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T07:57:43Z","timestamp":1425974263000},"page":"541-546","source":"Crossref","is-referenced-by-count":20,"title":["Unadjusted Plasma Renin Activity as a \u201cFirst\u2010Look\u201d Test to Decide Upon Further Investigations for Primary Aldosteronism"],"prefix":"10.1111","volume":"17","author":[{"given":"Peter","family":"Rye","sequence":"first","affiliation":[{"name":"Department of Medicine University of Calgary Calgary AB"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Chin","sequence":"additional","affiliation":[{"name":"Calgary Laboratory Services Department of Pathology and Laboratory Medicine Section of Clinical Biochemistry University of Calgary Calgary 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