{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T16:27:21Z","timestamp":1775838441133,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T00:00:00Z","timestamp":1430092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"UT Southwestern O'Brien Kidney Center"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["RO1-HL 113738"],"award-info":[{"award-number":["RO1-HL 113738"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>Primary aldosteronism (<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>) is present in up to 20% of patients with treatment\u2010resistant hypertension (<jats:styled-content style=\"fixed-case\">TRH<\/jats:styled-content>). Investigation for <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">TRH<\/jats:styled-content> is recommended by current guidelines after medication nonadherence is excluded. Studies using therapeutic drug monitoring (<jats:styled-content style=\"fixed-case\">TDM<\/jats:styled-content>) have shown that &gt;50% of patients with <jats:styled-content style=\"fixed-case\">TRH<\/jats:styled-content> are nonadherent to their prescribed antihypertensive medications. However, the relationship between the prevalence of <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> and medication adherence as confirmed by <jats:styled-content style=\"fixed-case\">TDM<\/jats:styled-content> has not been\u00a0previously assessed. A retrospective analysis from a hypertension referral clinic showed that prevalence of <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> in adherent patients with <jats:styled-content style=\"fixed-case\">TRH<\/jats:styled-content> by <jats:styled-content style=\"fixed-case\">TDM<\/jats:styled-content> was significantly higher than in nonadherent patients (28% vs 8%, <jats:italic>P<\/jats:italic>&lt;.05). Furthermore, cost analysis showed that <jats:styled-content style=\"fixed-case\">TDM<\/jats:styled-content>\u2010guided <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> screening was $590.69 less expensive per patient, with minimal impact on the diagnostic accuracy. These data support a <jats:styled-content style=\"fixed-case\">TDM<\/jats:styled-content>\u2010guided <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> screening approach as a cost\u2010saving strategy compared with routine <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> screening for <jats:styled-content style=\"fixed-case\">TRH<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jch.12570","type":"journal-article","created":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T05:21:06Z","timestamp":1430198466000},"page":"713-719","source":"Crossref","is-referenced-by-count":23,"title":["Cost\u2010Effectiveness of Therapeutic Drug Monitoring in Diagnosing Primary Aldosteronism in Patients With Resistant Hypertension"],"prefix":"10.1111","volume":"17","author":[{"given":"Alejandro","family":"Velasco","sequence":"first","affiliation":[{"name":"Hypertension Section University of Texas Southwestern Medical Center Dallas 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