{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T22:37:29Z","timestamp":1785278249181,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Neurology Research Fund"},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["NSFC#81200892"],"award-info":[{"award-number":["NSFC#81200892"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>The authors hypothesized that both high and low pulse pressure (<jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content>) may predict cognitive decline in stroke\/transient ischemic attack (<jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content>) patients with white matter changes (<jats:styled-content style=\"fixed-case\">WMC<\/jats:styled-content>s). The authors prospectively followed up 406 ischemic stroke\/<jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content> patients with confluent <jats:styled-content style=\"fixed-case\">WMC<\/jats:styled-content>s over 18\u00a0months. <jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content> was measured at 3 to 6\u00a0months after stroke\/<jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content> and categorized into four groups by quartile. Cognition was assessed 3 to 6\u00a0months and 15 to 18\u00a0months after stroke\/<jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content> using the Clinical Dementia Rating and Mini\u2010Mental State Examination (<jats:styled-content style=\"fixed-case\">MMSE<\/jats:styled-content>). Logistic regression showed that patients in the first quartile of <jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content> had a 5.9\u2010fold higher risk for developing cognitive decline than patients in the third quartile (odds ratio, 5.9; 95% confidence interval, 1.7\u201320.6), while patients in the fourth quartile had a 3.5\u2010fold higher risk for cognitive decline than those in the third quartile (odds ratio, 3.5; 95% confidence interval, 1.0\u201312.4). This U\u2010shaped relationship was also evident between <jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content> and cognitive decline in <jats:styled-content style=\"fixed-case\">MMSE<\/jats:styled-content>, underlining the role of arterial stiffness and hypoperfusion in cognitive decline related to small vessel disease.<\/jats:p>","DOI":"10.1111\/jch.12583","type":"journal-article","created":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T06:18:19Z","timestamp":1433139499000},"page":"694-698","source":"Crossref","is-referenced-by-count":22,"title":["Pulse Pressure and Cognitive Decline in Stroke Patients With White Matter Changes"],"prefix":"10.1111","volume":"17","author":[{"given":"Zhaolu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Medicine and Therapeutics Lui Che Woo Institute of Innovative Medicine The Chinese University of Hong Kong Hong Kong 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