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A total of 105 patients with clinic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CBP<\/jats:styled-content>) \u2265140\/90\u00a0mm Hg with amlodipine 5\u00a0mg were randomly allocated to aliskiren (150\u2013300\u00a0mg)\/amlodipine (5\u00a0mg) (<jats:styled-content style=\"fixed-case\">ALI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content> group, n=53) or high\u2010dose amlodipine (10\u00a0mg) (h\u2010<jats:styled-content style=\"fixed-case\">dAML<\/jats:styled-content> group, n=52) and treated for 16\u00a0weeks. Each patient's <jats:styled-content style=\"fixed-case\">CBP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> ABPM<\/jats:styled-content>, urine albumin\u2010to\u2010creatinine ratio (<jats:styled-content style=\"fixed-case\">UACR<\/jats:styled-content>), and brachial\u2010ankle pulse wave velocity (ba<jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content>) were measured at baseline and at the end of the study. The <jats:styled-content style=\"fixed-case\">ALI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content> and h\u2010<jats:styled-content style=\"fixed-case\">dAML<\/jats:styled-content> groups showed similarly reduced mean 24\u2010hour <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>, daytime <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>, nighttime <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>, and ba<jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content>. However, <jats:styled-content style=\"fixed-case\">UACR<\/jats:styled-content> reduction was significantly greater in the <jats:styled-content style=\"fixed-case\">ALI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content> group (<jats:italic>P<\/jats:italic>=.02). <jats:styled-content style=\"fixed-case\">ALI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content> was significantly less effective in reducing early\u2010morning <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> (<jats:italic>P<\/jats:italic>=.002) and morning <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> surge (<jats:italic>P<\/jats:italic>=.001) compared with h\u2010<jats:styled-content style=\"fixed-case\">dAML<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jch.12618","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T22:53:02Z","timestamp":1436914382000},"page":"70-78","source":"Crossref","is-referenced-by-count":7,"title":["Differing Effects of Aliskiren\/Amlodipine Combination and High\u2010Dose Amlodipine Monotherapy on Ambulatory Blood Pressure and Target Organ Protection"],"prefix":"10.1111","volume":"18","author":[{"given":"Hiroyuki","family":"Mizuno","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine Jichi Medical University School of Medicine Tochigi Japan"},{"name":"Internal Medicine Fukushima Prefectural Minamiaizu Hospital Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Hoshide","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine Jichi Medical University School of Medicine Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoki","family":"Fukutomi","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine Jichi Medical University School of Medicine Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuomi","family":"Kario","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine Jichi Medical University School of Medicine Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12237"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000431740.32696.cc"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2014.20"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000154082.72286.2a"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.01.026"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr017"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.5.1236"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00932.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/hy0102.102293"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000146686.35541.29"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708379"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.107.740704"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208799"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.1954"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000160923.04524.5B"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022273"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2012.42"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60235-8"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70066-1"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.157149"},{"key":"e_1_2_8_22_1","first-page":"65","article-title":"Morning rise, morning surge and daytime variability of blood pressure and cardiovascular target organ damage. 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