{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T23:10:44Z","timestamp":1768259444854,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T00:00:00Z","timestamp":1438905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p>A growing body of evidence links obstructive sleep apnea (<jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>) with hypertension. The authors performed a retrospective cohort study using the University Hospital of Larissa Sleep Apnea Database (1501 patients) to determine predictors of in\u2010laboratory diagnosed <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> for development of hypertension. Differences in continuous variables were assessed via independent samples <jats:italic>t<\/jats:italic> test, whereas discrete variables were compared by Pearson's chi\u2010square test. Multivariate analysis was performed via discriminant function analysis. There were several significant differences between hypertensive and normotensive patients. Age, body mass index, comorbidity, daytime oxygen saturation, and indices of hypoxia during sleep were deemed the most accurate predictors of hypertension, whereas apnea\u2010hypopnea index and desaturation index were not. The single derived discriminant function was statistically significant (Wilk's lambda=0.771, \u03c7<jats:sup>2<\/jats:sup>=289.070<jats:italic>, P<\/jats:italic>&lt;.0001). Daytime and nocturnal hypoxia as consequences of chronic intermittent hypoxia play a central role in <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>\u2010related hypertension and should be further evaluated as possible severity markers in <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jch.12645","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T12:37:35Z","timestamp":1438951055000},"page":"146-152","source":"Crossref","is-referenced-by-count":20,"title":["Age, Body Mass Index, and Daytime and Nocturnal Hypoxia as Predictors of Hypertension in <scp>Patients With Obstructive Sleep Apnea<\/scp>"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0088-1608","authenticated-orcid":false,"given":"Georgios","family":"Natsios","sequence":"first","affiliation":[{"name":"Respiratory Medicine Department University Hospital of Larissa Larissa 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