{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T05:31:05Z","timestamp":1792992665703,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T00:00:00Z","timestamp":1442966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p>\n                    Patients receiving thiazide diuretics have a higher risk of impaired glucose tolerance or even incident diabetes, but the change of blood glucose level varies across different trials. The aim of this study was to investigate the glycemic changes in hypertensive patients with thiazide\u2010type diuretics. Twenty\u2010six randomized trials involving 16,162 participants were included. Thiazide\u2010type diuretics were found to increase fasting plasma glucose (\n                    <jats:styled-content style=\"fixed-case\">FPG<\/jats:styled-content>\n                    ) compared with nonthiazide agents or placebo or nontreatment (mean difference [MD], 0.27 mmol\/L [4.86 mg\/dL]; 95% confidence interval [CI], 0.15\u20130.39). Patients receiving lower doses of thiazides (hydrochlorothiazide or chlorthalidone \u226425 mg daily) had less change in\n                    <jats:styled-content style=\"fixed-case\">FPG<\/jats:styled-content>\n                    (\n                    <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\n                    , 0.15 mmol\/L [2.7 mg\/dL]; 95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    , 0.03\u20130.27) than those receiving higher doses (\n                    <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>\n                    , 0.60 mmol\/L [10.8 mg\/dL]; 95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    , 0.39\u20130.82), revealed by the subgroup analysis of thiazides vs calcium channel blockers. Thiazide\u2010type diuretics are associated with significant but small adverse glycemic effects in hypertensive patients. Treatment with a lower dose might reduce or avoid glycemic changes.\n                  <\/jats:p>","DOI":"10.1111\/jch.12679","type":"journal-article","created":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T09:03:23Z","timestamp":1442999003000},"page":"342-351","source":"Crossref","is-referenced-by-count":50,"title":["Association of Thiazide\u2010Type Diuretics With Glycemic Changes in Hypertensive Patients: A Systematic Review and Meta\u2010Analysis of Randomized Controlled Clinical Trials"],"prefix":"10.1111","volume":"18","author":[{"given":"Xiaodan","family":"Zhang","sequence":"first","affiliation":[{"name":"Intensive Care Unit Sun Yat\u2010sen University Cancer Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Sun Yat\u2010sen University Cancer Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.82.5.1616"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02527-7"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.284427"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60108-1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7176.2011.00575.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12215"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-008-0037-7"},{"key":"e_1_2_9_9_1","unstructured":"HigginsJ GreenS.Cochrane handbook for systematic reviews of intervention 5.1.0 (2011) Cochrane Collaboration.http:\/\/handbook.cochrane.org. 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