{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:58:03Z","timestamp":1793145483401,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,12,31]],"date-time":"2015-12-31T00:00:00Z","timestamp":1451520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hospital Regional Darcy Vargas"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>Thirty patients who underwent percutaneous renal denervation, which was performed by a single operator following the standard technique, were enrolled in this study. Patients with chronic kidney disease (<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>) stage 2 (n=19), 3 (n=6), and 4 (n=5) were included. Data were obtained at baseline and at monthly intervals for the first 6 months. At 7 months, follow\u2010up data were collected bimonthly until month 12, after which data were collected on a quarterly basis. Baseline blood pressure values (mean\u00b1<jats:styled-content style=\"fixed-case\">standard deviation<\/jats:styled-content>) were 185\u00b118\/107\u00b113 mm Hg in the office and 152\u00b117\/93\u00b111 mm Hg through 24\u2010hour ambulatory blood pressure monitoring (<jats:styled-content style=\"fixed-case\">ABPM<\/jats:styled-content>). Three patients with stage 4 <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> required chronic renal replacement therapy (one at the 13\u2010month follow\u2010up and two at the 14\u2010month follow\u2010up) after episodes of acute renal injury; their follow\u2010up was subsequently discontinued. The office blood pressure values at the 24\u2010month follow\u2010up were 131\u00b115\/87\u00b19 mm Hg (<jats:italic>P<\/jats:italic>&lt;.0001, for both comparisons); the corresponding <jats:styled-content style=\"fixed-case\">ABPM<\/jats:styled-content> values were 132\u00b114\/84\u00b112 mm Hg (<jats:italic>P<\/jats:italic>&lt;.0001, for both comparisons). The mean estimated glomerular filtration rate increased from 61.9\u00b123.9 <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\/min\/1.73 m<jats:sup>2<\/jats:sup> to 88.0\u00b139.8 <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\/min\/1.73 m<jats:sup>2<\/jats:sup> (<jats:italic>P<\/jats:italic>&lt;.0001). The urine albumin:creatinine ratio decreased from 99.8 mg\/g (<jats:styled-content style=\"fixed-case\">interquartile range,<\/jats:styled-content> 38.0\u2013192.1) to 11.0 mg\/g (<jats:styled-content style=\"fixed-case\">interquartile range,<\/jats:styled-content> 4.1\u201328.1; <jats:italic>P<\/jats:italic>&lt;.0001 mg\/g). At the end of the follow\u2010up period, 21 patients (70% of the initial sample) were no longer classified as having CKD.<\/jats:p>","DOI":"10.1111\/jch.12724","type":"journal-article","created":{"date-parts":[[2015,12,31]],"date-time":"2015-12-31T09:38:10Z","timestamp":1451554690000},"page":"190-196","source":"Crossref","is-referenced-by-count":54,"title":["Long\u2010Term Effects of Renal Sympathetic Denervation on Hypertensive Patients With Mild to Moderate Chronic Kidney Disease"],"prefix":"10.1111","volume":"18","author":[{"given":"M\u00e1rcio Galindo","family":"Kiuchi","sequence":"first","affiliation":[{"name":"Renal Division Department of Medicine Universidade Federal Fluminense Niter\u00f3i RJ Brazil"},{"name":"Hospital Regional Darcy Vargas Rio Bonito RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Luis","family":"Graciano","sequence":"additional","affiliation":[{"name":"Renal Division Department of Medicine Universidade Federal Fluminense Niter\u00f3i RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Angela Magalh\u00e3es de Queiroz","family":"Carreira","sequence":"additional","affiliation":[{"name":"Renal Division Department of Medicine Universidade Federal Fluminense Niter\u00f3i RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuaki","family":"Kiuchi","sequence":"additional","affiliation":[{"name":"Hospital Regional Darcy Vargas Rio Bonito RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai First People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"},{"name":"European Heart Rhythm Association\/European Society of Cardiology Department of Cardiology Elisabethinen University Teaching Hospital Linz Linz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocemir Ronaldo","family":"Lugon","sequence":"additional","affiliation":[{"name":"Renal Division Department of Medicine Universidade Federal Fluminense Niter\u00f3i RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.11.031"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002343"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2007.11.025"},{"key":"e_1_2_9_5_1","first-page":"89","article-title":"Catecholamines in peripheral venous plasma in patients on chronic haemodialysis","volume":"55","author":"McGrath BP","year":"1978","journal-title":"Clin Sci Mol Med"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008040402"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00552.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e32834db45d"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62192-3"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62039-9"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.300"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007050552"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00936.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1681\/ASN.V1181469","article-title":"Effects of low dose sympathetic inhibition on glomerulosclerosis and albuminuria in subtotally nephrectomized rats","volume":"11","author":"Amann K","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht200"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12415"},{"key":"e_1_2_9_17_1","doi-asserted-by":"crossref","unstructured":"DelacroixS Chokka RG Sahay S et al.Renal sympathetic denervation increases renal artery blood flow: a serial MRI study in resistant hypertension. 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