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The Azilsartan Circadian and Sleep Pressure\u2013\u2013the First Study (<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>1) trial was a multicentered, randomized, open\u2010label, two\u2010parallel group study comparing the effects of an angiotensin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> receptor blocker (azilsartan) and a calcium channel blocker (amlodipine). The present study is a post hoc analysis of <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>1 to investigate age\u2010 and sex\u2010related differences in the antihypertensive effects between azilsartan and amlodipine. Azilsartan significantly reduced diastolic blood pressure in male patients younger than 60 years compared with amlodipine, but amlodipine significantly reduced systolic blood pressure in female patients 60 years and older compared with azilsartan. A randomized controlled trial to evaluate cardiovascular outcomes will demonstrate whether a diastolic blood pressure\u2013lowering effect with azilsartan is significantly effective in male patients younger than 60 years.<\/jats:p>","DOI":"10.1111\/jch.12733","type":"journal-article","created":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T05:22:46Z","timestamp":1446787366000},"page":"672-678","source":"Crossref","is-referenced-by-count":11,"title":["Age\u2010 and Sex\u2010Related Differences in Efficacy With an Angiotensin II Receptor Blocker and a Calcium Channel Blocker in Asian Hypertensive Patients"],"prefix":"10.1111","volume":"18","author":[{"given":"Kazuomi","family":"Kario","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Departments of Medicine and Sleep and Circadian Cardiology Jichi Medical University School of Medicine Shimotsuke Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Hoshide","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Departments of Medicine and Sleep and Circadian Cardiology Jichi Medical University School of Medicine Shimotsuke Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.284427"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12237"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2014.20"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.004876"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.10.060"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32835d8230"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht151"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBP.0000000000000032"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.04935"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(00)01266-8"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060838"},{"key":"e_1_2_9_13_1","unstructured":"Ministry of Health Labour and Welfare.Country\u2010specific smoking rates in adults (WHO: Tobacco Atlas 2002). 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