{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T21:37:50Z","timestamp":1788212270540,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T00:00:00Z","timestamp":1450742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>Triglyceride (<jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>) to high\u2010density lipoprotein cholesterol (<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>\u2010C) ratio (<jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>\u2010C) has been suggested as a simple method to identify unfavorable cardiovascular outcomes in the general population. The effect of the <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>\u2010C ratio on essential hypertensive patients is unclear. About 900 consecutive essential hypertensive patients (mean age 52.9\u00b112.6 years, 54.2% male) who visited our outpatient hypertension clinic were analyzed. Participants were divided into quartiles based on baseline <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>\u2010C ratio and medical records were obtained periodically for the occurrence of fatal events and composite major adverse cardiovascular events (<jats:styled-content style=\"fixed-case\">MACEs<\/jats:styled-content>) including transient ischemic attack, stroke, aortic dissection, acute coronary syndrome, and death. Participants were followed for a median of 40 months (interquartile range, 35\u201344 months). Overall, a higher quartile of <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>\u2010C ratio at baseline was significantly linked with higher incidence of fatal and nonfatal cardiovascular events. Using multivariate Cox regression analysis, plasma <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>\u2010C ratio was independently associated with increased risk of fatal events (hazard ratio [<jats:styled-content style=\"fixed-case\">HR],<\/jats:styled-content> 1.25; 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI]<\/jats:styled-content>, 1.13\u20131.37; <jats:italic>P<\/jats:italic>\u2264.001] and <jats:styled-content style=\"fixed-case\">MACEs<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HR,<\/jats:styled-content> 1.13; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.06\u20131.21; <jats:italic>P<\/jats:italic>\u2264.001). Increased plasma <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>\u2010C ratio was associated with more fatal events and <jats:styled-content style=\"fixed-case\">MACEs<\/jats:styled-content> in essential hypertensive patients.<\/jats:p>","DOI":"10.1111\/jch.12758","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T04:08:42Z","timestamp":1450843722000},"page":"772-777","source":"Crossref","is-referenced-by-count":57,"title":["The Role of Plasma Triglyceride\/High\u2010Density Lipoprotein Cholesterol Ratio to Predict New Cardiovascular Events in Essential Hypertensive Patients"],"prefix":"10.1111","volume":"18","author":[{"given":"Osman","family":"Turak","sequence":"first","affiliation":[{"name":"Department of Cardiology T\u00fcrkiyeY\u00fcksekIhtisas Education and Research Hospital Ankara Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bar\u0131\u015f","family":"Af\u015far","sequence":"additional","affiliation":[{"name":"Department of Nephrology Konya Numune Hospital Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u0131rat","family":"Ozcan","sequence":"additional","affiliation":[{"name":"Department of Cardiology T\u00fcrkiyeY\u00fcksekIhtisas Education and Research Hospital Ankara Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"\u00d6ks\u00fcz","sequence":"additional","affiliation":[{"name":"Department of Cardiology T\u00fcrkiyeY\u00fcksekIhtisas Education and Research Hospital Ankara Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Ali","family":"Mendi","sequence":"additional","affiliation":[{"name":"Department of Cardiology T\u00fcrkiyeY\u00fcksekIhtisas Education and Research Hospital Ankara Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c7agr\u0131","family":"Yayla","sequence":"additional","affiliation":[{"name":"Department of Cardiology T\u00fcrkiyeY\u00fcksekIhtisas Education and Research Hospital Ankara Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Covic","sequence":"additional","affiliation":[{"name":"Nephrology Clinic Dialysis and Renal Transplant Center C.I. 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