{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T11:01:19Z","timestamp":1793703679334,"version":"4.5.1"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,1,17]],"date-time":"2016-01-17T00:00:00Z","timestamp":1452988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>The authors aimed to investigate the superiority of angiotensin system blockade (angiotensin\u2010converting enzyme [ACE] inhibitor\/angiotensin receptor blocker [<jats:styled-content style=\"fixed-case\">ARB<\/jats:styled-content>]) plus a calcium channel blocker (<jats:styled-content style=\"fixed-case\">CCB<\/jats:styled-content>) (A+C) over other combination therapies in antihypertensive treatment. A meta\u2010analysis in 20,451 hypertensive patients from eight randomized controlled trials was conducted to compare the A+C treatment with other combination therapies in terms of blood pressure (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) reduction, clinical outcomes, and adverse events. The results showed that <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> reduction did not differ significantly among the A+C therapy and other combination therapies in systolic and diastolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> (<jats:italic>P<\/jats:italic>=.87 and <jats:italic>P<\/jats:italic>=.56, respectively). However, A+C therapy, compared with other combination therapies, achieved a significantly lower incidence of cardiovascular composite endpoints, including cardiovascular mortality, nonfatal myocardial infarction, and nonfatal stroke (risk ratio [RR], 0.80; 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>], 0.70\u20130.91; <jats:italic>P<\/jats:italic>&lt;.001), but similar all\u2010cause mortality (RR, 0.90; 95% CI, 0.77\u20131.04; <jats:italic>P<\/jats:italic>=.15) and stroke rates (RR, 0.90; 95% CI, 0.77\u20131.04; <jats:italic>P<\/jats:italic>=.09). Moreover, A+C therapy yielded a 4.21 mL\/min\/1.73 m<jats:sup>2<\/jats:sup> lower estimated glomerular filtration rate reduction than other combinations (<jats:italic>P<\/jats:italic>&lt;.001). Finally, A+C therapy showed a similar incidence of adverse events as other combination therapies (<jats:italic>P<\/jats:italic>=.34) but presented a significantly lower incidence of serious adverse events (RR, 0.85; 95% CI, 0.73\u20130.98; <jats:italic>P<\/jats:italic>=.03). In conclusion, A+C therapy is superior to other combinations of antihypertensive treatment as it shows a lower incidence of cardiovascular events and adverse events, while it has similar effects in lowering <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> and preserving renal function.<\/jats:p>","DOI":"10.1111\/jch.12771","type":"journal-article","created":{"date-parts":[[2016,1,18]],"date-time":"2016-01-18T04:44:43Z","timestamp":1453092283000},"page":"801-808","source":"Crossref","is-referenced-by-count":28,"title":["Angiotensin System Blockade Combined With Calcium Channel Blockers Is Superior to Other Combinations in Cardiovascular Protection With Similar Blood Pressure Reduction: A Meta\u2010Analysis in 20,451 Hypertensive Patients"],"prefix":"10.1111","volume":"18","author":[{"given":"Chen","family":"Chi","sequence":"first","affiliation":[{"name":"Department of Cardiology Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai 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