{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:20:53Z","timestamp":1773296453352,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T00:00:00Z","timestamp":1453939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>Hypertension is the main risk factor for both white matter lesions (<jats:styled-content style=\"fixed-case\">WMLs<\/jats:styled-content>) and stroke, but many stroke patients do not have <jats:styled-content style=\"fixed-case\">WMLs<\/jats:styled-content>. To find specific determinants of <jats:styled-content style=\"fixed-case\">WMLs<\/jats:styled-content>, the authors assessed 321 ischemic and hemorrhagic stroke patients who had undergone echocardiography. The patients with <jats:styled-content style=\"fixed-case\">WMLs<\/jats:styled-content> (n=160) were more often hypertensive and had a higher systolic blood pressure than the patients without <jats:styled-content style=\"fixed-case\">WMLs<\/jats:styled-content>. However, in a multivariate analysis, only the following variables remained associated with <jats:styled-content style=\"fixed-case\">WMLs<\/jats:styled-content>: (1) age: <jats:styled-content style=\"fixed-case\">odds ratio [OR]<\/jats:styled-content>, 1.08 per year (95% confidence interval [CI], 1.06\u20131.11); (2) left ventricular relative wall thickness (<jats:styled-content style=\"fixed-case\">RWT<\/jats:styled-content>) \u22650.52: OR, 2.78 (95% CI, 1.59\u20134.88); (3) lacunar strokes: OR, 4.15 (95% CI, 1.83\u20139.44); (4) hemorrhagic strokes: OR, 5.36 (95% CI, 1.57\u201318.39); and (5) female: OR, 1.91 (95% CI, 1.12\u20133.27). Thus, the main modifiable risk factor for <jats:styled-content style=\"fixed-case\">WMLs<\/jats:styled-content> was <jats:styled-content style=\"fixed-case\">RWT<\/jats:styled-content>, which proved to be an even stronger risk factor than hypertension. This suggests that <jats:styled-content style=\"fixed-case\">RWT<\/jats:styled-content> might be a useful target in the treatment of hypertension to counteract the appearance of <jats:styled-content style=\"fixed-case\">WMLs<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jch.12788","type":"journal-article","created":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T04:48:54Z","timestamp":1454042934000},"page":"907-912","source":"Crossref","is-referenced-by-count":9,"title":["Hypertension and Other Determinants of White Matter Lesions in Stroke Patients"],"prefix":"10.1111","volume":"18","author":[{"given":"Antonio","family":"Muscari","sequence":"first","affiliation":[{"name":"Stroke Unit \u2013 Medical Department of Continuity of Care and Disability S.Orsola\u2010Malpighi Hospital Bologna Italy"},{"name":"Department of Medical and Surgical Sciences University of Bologna S.Orsola\u2010Malpighi Hospital Bologna 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