{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T17:52:44Z","timestamp":1771005164384,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,3,16]],"date-time":"2016-03-16T00:00:00Z","timestamp":1458086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004198","name":"Waksman Foundation for Microbiology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004198","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>It has long been thought that there is a close association between hypertension and atrial fibrillation (<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>). However, the efficacy of an angiotensin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> receptor blocker for the prevention of organ damage in hypertensive individuals with <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> is still controversial. The present study was a multicentered, prospective, randomized, open\u2010label clinical trial investigating the differences in the effect of treatment with telmisartan\/amlodipine combination tablets on blood pressure (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) levels and <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> variability between morning and bedtime administration in hypertensive patients with paroxysmal <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>, using ambulatory <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> monitoring (<jats:styled-content style=\"fixed-case\">ABPM<\/jats:styled-content>) and home <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>. With this treatment, the patients' 24\u2010hour <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>, nighttime <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>, preawake <jats:styled-content style=\"fixed-case\">BP,<\/jats:styled-content> and morning <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> shown by <jats:styled-content style=\"fixed-case\">ABPM<\/jats:styled-content> were significantly reduced, and the antihypertensive effects were similar regardless of the timing of the drug administration. The standard deviation of day\u2010by\u2010day home systolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> and the maximum home <jats:styled-content style=\"fixed-case\">systolic BP<\/jats:styled-content> were also significantly reduced, and these effects were similar regardless of the treatment timing. The N\u2010terminal pro\u2010brain natriuretic peptide level was significantly decreased only in the bedtime administration group. A larger study will demonstrate whether the bedtime administration of telmisartan\/amlodipine combination tablets maximizes the risk\u2010lowering effect against <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> recurrence in paroxysmal <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> hypertensive patients.<\/jats:p>","DOI":"10.1111\/jch.12814","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T02:12:57Z","timestamp":1458353577000},"page":"1036-1044","source":"Crossref","is-referenced-by-count":21,"title":["Dose Timing of an Angiotensin <scp>II<\/scp> Receptor Blocker\/Calcium Channel Blocker Combination in Hypertensive Patients With Paroxysmal Atrial Fibrillation"],"prefix":"10.1111","volume":"18","author":[{"given":"Kazuomi","family":"Kario","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine and Department of Sleep and Circadian Cardiology Jichi Medical 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