{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:19:03Z","timestamp":1791494343234,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T00:00:00Z","timestamp":1465776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Pfizer Japan Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>The authors aimed to investigate the blood pressure (BP)\u2013lowering ability of eplerenone in drug\u2010resistant hypertensive patients. A total of 57 drug\u2010resistant hypertensive patients whose home <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> was \u2265135\/85 mm Hg were investigated. The patients were randomized to either an eplerenone group or a control group and followed for 12 weeks. The efficacy was evaluated by clinic, home, and ambulatory <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> monitoring. Urinary albumin, pulse wave velocity, and flow\u2010mediated vasodilation (<jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content>) were also evaluated. Home morning systolic BP (148\u00b115 vs 140\u00b115 mm Hg) and evening systolic BP (137\u00b116 vs 130\u00b116 mm Hg) were significantly lowered in the eplerenone group (n=35) compared with baseline (both <jats:italic>P<\/jats:italic>&lt;.05), while unchanged in the control group (n=22). <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> reductions in the eplerenone group were most pronounced for ambulatory awake systolic BP (<jats:italic>P<\/jats:italic>=.04), awake diastolic BP (<jats:italic>P<\/jats:italic>=.004), and 24\u2010hour diastolic BP (<jats:italic>P<\/jats:italic>=.02). <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content> was significantly improved in the eplerenone group. In patients with drug\u2010resistant hypertension, add\u2010on use of eplerenone was effective in lowering <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>, especially home and ambulatory awake <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jch.12860","type":"journal-article","created":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T07:17:08Z","timestamp":1465888628000},"page":"1250-1257","source":"Crossref","is-referenced-by-count":26,"title":["Add\u2010On Use of Eplerenone Is Effective for Lowering Home and Ambulatory Blood Pressure in Drug\u2010Resistant Hypertension"],"prefix":"10.1111","volume":"18","author":[{"given":"Kazuo","family":"Eguchi","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine Jichi Medical University School of Medicine Tochigi 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