{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:54:01Z","timestamp":1776128041178,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T00:00:00Z","timestamp":1469059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>Patients with both hypertension and hyperhomocysteinemia, termed H\u2010type hypertension, have a high risk for cardiocerebrovascular diseases. However, little is known about the prevalence of H\u2010type hypertension or its role in target organ damage in patients with chronic kidney disease (<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>). The authors recruited 1042 patients with <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> who were admitted to their hospital division. Multiple linear regression analyses were used to evaluate the association between H\u2010type hypertension and renal\/cardiovascular parameters. A total of 460 (44.14%) <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> patients had H\u2010type hypertension. Multivariate logistic regression analysis showed that H\u2010type hypertension is associated with serum albumin, uric acid, estimated glomerular filtration rate (<jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>), and 24\u2010hour systolic blood pressure. Patients with H\u2010type hypertension had the worst renal function and left ventricular hypertrophy among all patients, while the levels of carotid intima\u2010media thickness (<jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content>) in patients with H\u2010type hypertension were only slightly higher than in patients with normotension and normohomocysteinemia (<jats:italic>P<\/jats:italic>&lt;.05). H\u2010type hypertension was associated with <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>, left ventricular mass index, and <jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content> according to multiple linear regression analyses. The prevalence of H\u2010type hypertension was high and H\u2010type hypertension was associated with target organ damage in patients with CKD.<\/jats:p>","DOI":"10.1111\/jch.12881","type":"journal-article","created":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T07:12:48Z","timestamp":1469085168000},"page":"151-160","source":"Crossref","is-referenced-by-count":30,"title":["Prevalence of Homocysteine\u2010Related Hypertension in Patients With Chronic Kidney Disease"],"prefix":"10.1111","volume":"19","author":[{"given":"Zengchun","family":"Ye","sequence":"first","affiliation":[{"name":"Division of Nephrology Department of Medicine Third Affiliated Hospital of Sun Yat\u2010Sen University, Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Third Affiliated Hospital of Sun Yat\u2010Sen University, Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qunzi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Third Affiliated Hospital of Sun Yat\u2010Sen University, Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Third Affiliated Hospital of Sun Yat\u2010Sen University, Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Third Affiliated Hospital of Sun Yat\u2010Sen University, Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XinXin","family":"Ma","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Third Affiliated Hospital of Sun Yat\u2010Sen University, Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Peng","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Third Affiliated Hospital of Sun Yat\u2010Sen University, Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanqi","family":"Lou","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Third Affiliated Hospital of Sun Yat\u2010Sen University, Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084943"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60033-6"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.114"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2009007500021"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu6041649"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.16.2015"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-14-6"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2014.10.014"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16268"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.2274"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2010.07.013"},{"key":"e_1_2_10_13_1","first-page":"421","article-title":"Effect of folic acid intervention on the change of serum folate level in hypertensive Chinese adults: do methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms affect therapeutic responses? 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