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After comparing 51 adults with <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content> and 51 healthy adults (siblings of <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content> individuals), the authors found that adults with <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content> seem to have lower arterial stiffness, as a result of chronic hypotension. Subclinical atherosclerosis parameters do not correlate with traditional cardiovascular risk factors in adults with <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>, thus raising the hypothesis that classic predictive models for cardiovascular disease are not valid in this population. Hyperparathyroidism could play an important role in arterial damage in these individuals. The lower than expected prevalence of obesity and dyslipidemia could be explained by better eating habits, with this study being the first to address the anthropometric and clinical profile of a Mediterranean cohort of adults with DS.<\/jats:p>","DOI":"10.1111\/jch.12890","type":"journal-article","created":{"date-parts":[[2016,8,6]],"date-time":"2016-08-06T12:08:56Z","timestamp":1470485336000},"page":"205-211","source":"Crossref","is-referenced-by-count":23,"title":["Atherosclerotic Surrogate Markers in Adults With Down Syndrome: A Case\u2010Control Study"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6914-9693","authenticated-orcid":false,"given":"Pedro","family":"Parra","sequence":"first","affiliation":[{"name":"Adult Down Syndrome Outpatient Unit Department of Internal Medicine Fundaci\u00f3n de Investigaci\u00f3n Biom\u00e9dica Hospital Universitario de La Princesa Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Costa","sequence":"additional","affiliation":[{"name":"Adult Down Syndrome Outpatient Unit Department of Internal Medicine Fundaci\u00f3n de Investigaci\u00f3n Biom\u00e9dica Hospital Universitario de La Princesa Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego Real","family":"de As\u00faa","sequence":"additional","affiliation":[{"name":"Adult Down Syndrome Outpatient Unit Department of Internal Medicine Fundaci\u00f3n de Investigaci\u00f3n Biom\u00e9dica Hospital Universitario de La Princesa Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Moldenhauer","sequence":"additional","affiliation":[{"name":"Adult Down Syndrome Outpatient Unit Department of Internal Medicine Fundaci\u00f3n de Investigaci\u00f3n Biom\u00e9dica Hospital Universitario de La Princesa Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Adult Down Syndrome Outpatient Unit Department of Internal Medicine Fundaci\u00f3n de Investigaci\u00f3n Biom\u00e9dica Hospital Universitario de La Princesa Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs092"},{"key":"e_1_2_9_3_1","unstructured":"SIGN (Scottish Intercollegiate Guidelines Network).Risk Estimation and the Prevention of Cardiovascular Disease. 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