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In this post hoc analysis, seated blood pressure, heart rate, 24\u2010hour ambulatory <jats:styled-content style=\"fixed-case\">blood pressure<\/jats:styled-content> monitoring, plasma aldosterone, estimated glomerular filtration rate, and safety measures were assessed in obese (body mass index &gt;32\u00a0kg\/m<jats:sup>2<\/jats:sup>; n=1823) and nonobese (<jats:styled-content style=\"fixed-case\">body mass index<\/jats:styled-content> &lt;27\u00a0kg\/m<jats:sup>2<\/jats:sup>; n=847) adults with hypertension (stage I or <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>) treated with nebivolol\u2010valsartan <jats:styled-content style=\"fixed-case\">SPC<\/jats:styled-content>s, nebivolol or valsartan monotherapy, or placebo. At week 8, reductions from baseline in <jats:styled-content style=\"fixed-case\">blood pressure<\/jats:styled-content> and ambulatory blood pressure monitoring were greater with <jats:styled-content style=\"fixed-case\">SPC<\/jats:styled-content>s and most nebivolol and valsartan monotherapy doses vs placebo regardless of obesity status. Aldosterone declined with all active treatments and <jats:styled-content style=\"fixed-case\">estimated glomerular filtration rate<\/jats:styled-content> remained steady. The nebivolol\u2010valsartan 5\/80\u00a0mg\/d <jats:styled-content style=\"fixed-case\">SPC<\/jats:styled-content> was efficacious regardless of degree of obesity.<\/jats:p>","DOI":"10.1111\/jch.12965","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T12:32:40Z","timestamp":1484137960000},"page":"632-639","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy of nebivolol\u2010valsartan single\u2010pill combination in obese and nonobese patients with hypertension"],"prefix":"10.1111","volume":"19","author":[{"given":"Christian W.","family":"Mende","sequence":"first","affiliation":[{"name":"University of California  San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas D.","family":"Giles","sequence":"additional","affiliation":[{"name":"Tulane University  New Orleans LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David 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