{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:26:18Z","timestamp":1761017178414},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T00:00:00Z","timestamp":1486512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>Angiotensin\u2010converting enzyme inhibitors (<jats:styled-content style=\"fixed-case\">ACEIs<\/jats:styled-content>) and angiotensin receptor blockers (<jats:styled-content style=\"fixed-case\">ARB<\/jats:styled-content>s) have become standards of care for diabetic nephropathy. The authors assessed the association between treatment adherence to <jats:styled-content style=\"fixed-case\">ACEIs<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ARBs<\/jats:styled-content> and the development of end\u2010stage renal disease (<jats:styled-content style=\"fixed-case\">ESRD<\/jats:styled-content>). The cohort comprised the 9895 members of the Central District of Clalit Health Services aged 40 to 70\u00a0years, diagnosed with diabetes before 2002, who filled at least four <jats:styled-content style=\"fixed-case\">ACEI<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">ARB<\/jats:styled-content> monthly prescriptions during 2002\u20132011. Forty\u2010six percent of patients made 10 or more purchases a year. Hazard ratios for <jats:styled-content style=\"fixed-case\">ESRD<\/jats:styled-content> development and death decreased as adherence increased, with no evidence of a cutoff threshold or plateau. For both outcomes, hazard ratios were significantly lower among patients who purchased at least 10 monthly prescriptions (83% adherence), after adjusting for age, sex, and a number of clinically relevant factors. While <jats:styled-content style=\"fixed-case\">ACEI<\/jats:styled-content>s\/<jats:styled-content style=\"fixed-case\">ARB<\/jats:styled-content>s have become standards of care in diabetes, treatment adherence is essential to achieve full benefit.<\/jats:p>","DOI":"10.1111\/jch.12976","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T11:26:44Z","timestamp":1486553204000},"page":"627-631","source":"Crossref","is-referenced-by-count":4,"title":["End\u2010stage renal disease and adherence to angiotensin\u2010converting enzyme inhibitors and angiotensin receptor blockers among patients with diabetes"],"prefix":"10.1111","volume":"19","author":[{"given":"Michal","family":"Shani","sequence":"first","affiliation":[{"name":"Family Medicine Department, Central District Clalit Health Service  Mazkeret Batya Israel"},{"name":"Sackler School of Medicine Tel\u2010Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shlomo","family":"Vinker","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine Tel\u2010Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonid","family":"Feldman","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine Tel\u2010Aviv University  Tel Aviv Israel"},{"name":"Nephrology Department Assaf Harofeh Medical Center  Zerifin Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,8]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Renal Replacement Therapy in Israel 1990\u20132010.www.health.gov.il\/publicationsfiles\/RRTI1990_2010.pdf. 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