{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:28:35Z","timestamp":1789766915362,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T00:00:00Z","timestamp":1487289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KFO 106"],"award-info":[{"award-number":["KFO 106"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TP5"],"award-info":[{"award-number":["TP5"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2017,7]]},"abstract":"Abstract<\/jats:title>Vascular damage is aggravated in animal models of hypertension with mineralocorticoid (MR<\/jats:styled-content>) excess and in hypertensive patients with primary hyperaldosteronism. MR<\/jats:styled-content> antagonism has shown to provide effective blood pressure (BP<\/jats:styled-content>)\u2010control in patients with treatment resistant hypertension (TRH<\/jats:styled-content>), but the concurrent effects on the vasculature have not been examined. In a randomized, double\u2010blinded, placebo\u2010controlled parallel\u2010group study, 51 patients with TRH<\/jats:styled-content> received either eplerenone 50 mg or placebo for 6\u00a0months together with additional antihypertensives titrated to achieve a BP<\/jats:styled-content> target of <140\/90\u00a0mm\u00a0Hg. Pulse wave velocity (PWV<\/jats:styled-content>), augmentation index (AI<\/jats:styled-content>x), augmentation pressure (AP<\/jats:styled-content>), AP<\/jats:styled-content> normalized to a heart rate of 75\/min (AP<\/jats:styled-content>@HR<\/jats:styled-content>75), renal resistive index (RRI<\/jats:styled-content>), intima\u2010media thickness (IMT<\/jats:styled-content>) and urinary albumin excretion rate (UAER<\/jats:styled-content>) were assessed before and after treatment. PWV<\/jats:styled-content> was reduced only with eplerenone (from 11.3\u00b13.6 to 9.8\u00b12.6\u00a0m\/s, P<\/jats:italic>\u02c2.001), but not with placebo (10.3\u00b12.0 to 10.1\u00b11.8\u00a0m\/s, P<\/jats:italic>=.60), despite similar reductions in BP<\/jats:styled-content> (\u221235\u00b120\/\u221215\u00b111\u00a0mm\u00a0Hg vs \u221230\u00b119\/\u221213\u00b17\u00a0mm\u00a0Hg, n.s.). Further, reductions in AP<\/jats:styled-content> and AP<\/jats:styled-content>@HR<\/jats:styled-content>75 were greater with eplerenone, while changes in AI<\/jats:styled-content>x, RRI<\/jats:styled-content>, IMT<\/jats:styled-content> and UAER<\/jats:styled-content> were similar. Our data show that eplerenone beneficially affects markers of arterial stiffness and wave reflection in patients with TRH<\/jats:styled-content>, independently of BP<\/jats:styled-content> lowering. These data add to the evidence that MR<\/jats:styled-content> antagonism should be the preferred treatment option in TRH<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jch.12986","type":"journal-article","created":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T05:22:44Z","timestamp":1487308964000},"page":"669-676","source":"Crossref","is-referenced-by-count":32,"title":["Low dose\u2010eplerenone treatment decreases aortic stiffness in patients with resistant hypertension"],"prefix":"10.1111","volume":"19","author":[{"given":"Tatjana","family":"Kalizki","sequence":"first","affiliation":[{"name":"Department of Nephrology and Hypertension University Hospital of the Friedrich\u2010Alexander\u2010University Erlangen\u2010N\u00fcrnberg Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard M.W.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension Hannover Medical School Hannover 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