{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:49:22Z","timestamp":1747198162915,"version":"3.37.3"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T00:00:00Z","timestamp":1488844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003810","name":"Hospital de Cl\u00ednicas de Porto Alegre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003810","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Obstructive sleep apnea (<jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>) is a common cause of high blood pressure (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>). Many patients, however, have uncontrolled <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> because of nonadherence to antihypertensive medication. The possibility that <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> influences adherence has not been investigated to date. The authors sought to explore the possible association between high risk of <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> and nonadherence. This study was carried out in a hypertension outpatient clinic. Adherence to medication, high risk of <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>, and sleepiness were evaluated in a cross\u2010sectional study. These variables were identified using the eight\u2010item Morisky, <jats:styled-content style=\"fixed-case\">STOP<\/jats:styled-content>\u2010Bang, and Epworth scales, respectively. A total of 416 patients with hypertension were enrolled (32% male, aged 65\u00b111\u00a0years). Nonadherence was identified in 71 (17%) individuals. The prevalence of high risk of <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> was 323 (78%) and of somnolence was 136 (33%). High risk of <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> was associated with nonadherence, showing a prevalence ratio (<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>) of 2.6 (95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>], 1.3\u20135.6) and retained significance after adjustment for sleepiness (<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>, 2.3; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.1\u20134.9 [<jats:italic>P<\/jats:italic>=.011]). Sleepiness was also associated with nonadherence (<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>, 1.7; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.1\u20132.6 [<jats:italic>P<\/jats:italic>=.003]). High risk of <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> and sleepiness are associated with nonadherence. These conditions, if treated, may allow for achieving better outcomes and improvement of adherence to medication.<\/jats:p>","DOI":"10.1111\/jch.12992","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T12:03:20Z","timestamp":1488888200000},"page":"534-539","source":"Crossref","is-referenced-by-count":11,"title":["Influence of high risk of obstructive sleep apnea on adherence to antihypertensive treatment in outpatients"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2441-3438","authenticated-orcid":false,"given":"Camila G.","family":"Righi","sequence":"first","affiliation":[{"name":"Graduate Studies Program in Cardiology School of Medicine Universidade Federal do Rio Grande do Sul  Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Martinez","sequence":"additional","affiliation":[{"name":"Graduate Studies Program in Cardiology School of Medicine Universidade Federal do Rio Grande do Sul  Porto Alegre RS Brazil"},{"name":"Division of Cardiology Hypertension and Sleep Clinics Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul  Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro C.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Graduate Studies Program in Cardiology School of Medicine Universidade Federal do Rio Grande do Sul  Porto Alegre RS Brazil"},{"name":"Division of Cardiology Hypertension and Sleep Clinics Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul  Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Gus","sequence":"additional","affiliation":[{"name":"Graduate Studies Program in Cardiology School of Medicine Universidade Federal do Rio Grande do Sul  Porto Alegre RS Brazil"},{"name":"Division of Cardiology Hypertension and Sleep Clinics Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul  Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila B.","family":"Moreira","sequence":"additional","affiliation":[{"name":"Graduate Studies Program in Cardiology School of Medicine Universidade Federal do Rio Grande do Sul  Porto Alegre RS Brazil"},{"name":"Division of Cardiology Hypertension and Sleep Clinics Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul  Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6351-9588","authenticated-orcid":false,"given":"Sandra C.","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Graduate Studies Program in Cardiology School of Medicine Universidade Federal do Rio Grande do Sul  Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio D.","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Graduate Studies Program in Cardiology School of Medicine Universidade Federal do Rio Grande do Sul  Porto Alegre RS Brazil"},{"name":"Division of Cardiology Hypertension and Sleep Clinics Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul  Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,7]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"American Heart Association.Heart Disease and Stroke Statistics\u20142005 Update.Dallas TX:American Heart Association;2005."},{"key":"e_1_2_9_3_1","unstructured":"World Health Organization.Global Health Observatory\/Risk factors\/Raised blood pressure: Situation and trends.World Health Organization;2013.http:\/\/www.who.int\/mediacentre\/news\/releases\/2013\/world_health_day_20130403\/en\/. 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