{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:02:24Z","timestamp":1782889344307,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T00:00:00Z","timestamp":1493078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>This retrospective cohort study compared administration of lisinopril twice daily and once daily for hypertension. Data were collected from an ambulatory electronic health record between 2011 and 2014. Patients previously receiving lisinopril 20\u00a0mg were placed into the once\u2010daily cohort if changed to 40\u00a0mg once daily or into the twice\u2010daily cohort if changed to 20\u00a0mg twice daily. Efficacy outcome measures were change in systolic blood pressure and diastolic blood pressure and achievement of blood pressure control (&lt;140\/90\u00a0mm\u00a0Hg). Of 90 patients included (45 per cohort), the mean age was 61.8\u00a0years and 17.8% were black. Once\u2010 and twice\u2010daily administrations were associated with <jats:styled-content style=\"fixed-case\">blood pressure<\/jats:styled-content> reductions of 6.2\/1.5\u00a0mm\u00a0Hg and 16.5\/5.9\u00a0mm\u00a0Hg, with a 10.2\/4.3\u00a0mm\u00a0Hg greater reduction with twice\u2010daily administration (<jats:styled-content style=\"fixed-case\">systolic blood pressure<\/jats:styled-content>,<jats:italic> P<\/jats:italic>=.016; <jats:styled-content style=\"fixed-case\">diastolic blood pressure<\/jats:styled-content>,<jats:italic> P<\/jats:italic>=.068). Twice\u2010daily lisinopril dosing was associated with greater <jats:styled-content style=\"fixed-case\">systolic blood pressure<\/jats:styled-content> reductions compared with the same total daily dose administered once daily.<\/jats:p>","DOI":"10.1111\/jch.13011","type":"journal-article","created":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T08:58:06Z","timestamp":1493110686000},"page":"868-873","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy and safety of twice\u2010 vs once\u2010daily dosing of lisinopril for hypertension"],"prefix":"10.1111","volume":"19","author":[{"given":"Tiffany","family":"Tsai","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy Skaggs School of Pharmacy and Pharmaceutical Sciences University of Colorado Anschutz Medical Campus  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda E.","family":"Kroehl","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Informatics Colorado School of Public Health University of Colorado Anschutz Medical Campus  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Smith","sequence":"additional","affiliation":[{"name":"Departments of Pharmacotherapy &amp; Translational Research and Community Health &amp; Family Medicine Colleges of Pharmacy and Medicine University of Florida  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Skaggs School of Pharmacy and Pharmaceutical Sciences University of Colorado Anschutz Medical Campus  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella Y.","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Skaggs School of Pharmacy and Pharmaceutical Sciences University of Colorado Anschutz Medical Campus  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2041-7404","authenticated-orcid":false,"given":"Katy E.","family":"Trinkley","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Skaggs School of Pharmacy and Pharmaceutical Sciences University of Colorado Anschutz Medical Campus  Aurora CO USA"},{"name":"Department of Medicine School of Medicine University of Colorado Anschutz Medical Campus  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/circ.131.suppl_2.o29"},{"key":"e_1_2_8_3_1","volume-title":"Hypertension Among Adults in the United States, 2009\u20132010","author":"Yoon SS","year":"2012"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7176.2008.08021.x"},{"key":"e_1_2_8_5_1","first-page":"54","article-title":"Use of atenolol challenged as a suitable drug for hypertension","volume":"7","author":"Bloch MJ","year":"2005","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"e_1_2_8_6_1","unstructured":"IMS Institute for Healthcare Informatics.Medicines Use and Spending in the U.S. \u2010 A Review of 2015 and Outlook to 2020. 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