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Seventeen articles containing 24 studies with 270,284 participants were included in this meta\u2010analysis. The pooled relative risk of hypertension for the highest vs lowest category of oral contraceptive duration was 1.47 (95% confidence interval, 1.25\u20131.73), and excluding three studies with a relative risk &gt;3.0 yielded a pooled relative risk of 1.26 (95% confidence interval, 1.11\u20131.44). A linear dose\u2010response relationship was found (<jats:italic>P<\/jats:italic><jats:sub>nonlinearity<\/jats:sub>=0.69) and the risk of hypertension increased by 13% (relative risk, 1.13; 95% confidence interval, 1.03\u20131.25) for every 5\u2010year increment in oral contraceptive use. The duration of oral contraceptive use was positively associated with the risk of hypertension in this meta\u2010analysis.<\/jats:p>","DOI":"10.1111\/jch.13042","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T04:12:48Z","timestamp":1497413568000},"page":"1032-1041","source":"Crossref","is-referenced-by-count":74,"title":["Association between duration of oral contraceptive use and risk of hypertension: A meta\u2010analysis"],"prefix":"10.1111","volume":"19","author":[{"given":"Hui","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Health Statistics Qingdao University Medical College  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics Qingdao University Medical College  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics Qingdao University Medical College  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9308-9371","authenticated-orcid":false,"given":"Dongfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics Qingdao University Medical College  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1365.002"},{"key":"e_1_2_6_3_1","volume-title":"Trends in Contraceptive Use Worldwide 2015 (ST\/ESA\/SER.A\/349)","author":"United Nations, Department of Economic and Social Affairs, Population Division"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.06.056"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000435076.57585.21"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00212-0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-13-0298"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182994c43"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.09.042"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2012.11.002"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-013-0374-2"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-015-1392-3"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2010.67"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6874-13-39"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.3.483"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2007.01.007"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90569-S"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/AC.66.1.2064964"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12529-008-9019-z"},{"key":"e_1_2_6_20_1","first-page":"21","article-title":"Effects of long\u2010term oral contraceptives on women's blood pressure","volume":"10","author":"Chen C","year":"2002","journal-title":"Chin J Hypertension"},{"key":"e_1_2_6_21_1","first-page":"85","article-title":"Effects of long term oral contraceptive use on hypertension and coronary heart disease in 1180 women of childbearing age","volume":"34","author":"Zhao C","year":"2007","journal-title":"Cent Plains Med J"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1353\/hpu.2013.0172"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.24839"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.531913"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(96)00351-1"},{"key":"e_1_2_6_26_1","first-page":"412","article-title":"Oral contraceptives and hypertension. 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