{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T08:44:08Z","timestamp":1769244248255,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,29]],"date-time":"2017-07-29T00:00:00Z","timestamp":1501286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Drug Safety and Effectiveness Network of the Canadian Institutes of Health Research","award":["DPR-126990"],"award-info":[{"award-number":["DPR-126990"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2017,10]]},"abstract":"The authors compared the effectiveness of thiazide diuretic (TD<\/jats:styled-content>), angiotensin\u2010converting enzyme inhibitor (ACE<\/jats:styled-content>I), angiotensin receptor blocker (ARB<\/jats:styled-content>), and calcium channel blocker (CCB<\/jats:styled-content>) monotherapies for the treatment of nondiabetic hypertension using MarketScan Databases 2010\u20132014. Multivariable Cox regression models assessed whether the addition of a new antihypertensive drug, treatment discontinuation, or switch and major cardiovascular or cerebrovascular events varied across groups. A total of 565\u00a0009 patients started monotherapy with ACEIs<\/jats:styled-content> (43.6%), CCBs<\/jats:styled-content> (23.6%), TDs<\/jats:styled-content> (18.8%), or ARBs<\/jats:styled-content> (14.0%). Patients who took TDs had a higher risk for either drug addition or discontinuation than patients who took ACEIs<\/jats:styled-content> (hazard ratio [HR], 0.69 [95% CI<\/jats:styled-content>, 0.68\u20130.70] vs HR<\/jats:styled-content>, 0.81 [95% CI<\/jats:styled-content>, 0.80\u20130.81]), ARBs<\/jats:styled-content> (HR<\/jats:styled-content>, 0.67 [95% CI<\/jats:styled-content>, 0.66\u20130.68] vs HR<\/jats:styled-content>, 0.66 [95% CI<\/jats:styled-content>, 0.65\u20130.67]), and CCBs<\/jats:styled-content> (HR<\/jats:styled-content>, 0.85 [95% CI<\/jats:styled-content>, 0.84\u20130.87] vs HR<\/jats:styled-content>, 0.94 [95% CI<\/jats:styled-content>, 0.93\u20130.95]). Conversely, patients who took TDs experienced a lower risk of clinical events compared with patients who took ACE<\/jats:styled-content>Is (HR<\/jats:styled-content>, 1.24 [95% CI<\/jats:styled-content>, 1.15\u20131.33]), ARBs<\/jats:styled-content> (HR<\/jats:styled-content>, 1.28 [95% CI<\/jats:styled-content>, 1.18\u20131.39]), and CCBs<\/jats:styled-content> (HR<\/jats:styled-content>, 1.35 [95% CI<\/jats:styled-content>, 1.25\u20131.46]). Our results provide a strong rationale for choosing TD<\/jats:styled-content>s as first\u2010line monotherapy for the control of hypertension.<\/jats:p>","DOI":"10.1111\/jch.13055","type":"journal-article","created":{"date-parts":[[2017,7,29]],"date-time":"2017-07-29T05:12:37Z","timestamp":1501305157000},"page":"999-1009","source":"Crossref","is-referenced-by-count":8,"title":["Comparative effectiveness of antihypertensive drugs in nondiabetic patients with hypertension: A population\u2010based study"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9625-0340","authenticated-orcid":false,"given":"Marina Amaral de \u00c1vila","family":"Machado","sequence":"first","affiliation":[{"name":"Division of Clinical Epidemiology McGill University Health Center Research Institute Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiano Soares","family":"de Moura","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology McGill University Health Center Research Institute Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yishu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Biostatistics and Occupational Health McGill University Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coraline","family":"Danieli","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Biostatistics and Occupational Health McGill University Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Abrahamowicz","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology and Department of Epidemiology Biostatistics and Occupational Health McGill University and McGill University Health Center Research Institute Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasha","family":"Bernatsky","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology and Department of Epidemiology Biostatistics and Occupational Health McGill University and McGill University Health Center Research Institute Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Behlouli","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology McGill University Health Center Research Institute Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Pilote","sequence":"additional","affiliation":[{"name":"Divisions of General Internal Medicine and Clinical Epidemiology Department of Medicine McGill University and McGill University Health Center Research Institute Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060308"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1000949"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.04.026"},{"key":"e_1_2_10_5_1","first-page":"e38","article-title":"Heart disease and stroke statistics\u20142016 update: a report from the American Heart Association","volume":"133","author":"Mozaffarian D","year":"2016","journal-title":"Circulation"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1406751"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.284427"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-6175.2004.03044.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-3-18"},{"key":"e_1_2_10_10_1","first-page":"CD001841","article-title":"First\u2010line drugs for hypertension","volume":"3","author":"Wright JM","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.23.2981"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.130"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-3-200908040-00125"},{"key":"e_1_2_10_14_1","unstructured":"Truven Health Analytics.Research data and analytic tools.http:\/\/truvenhealth.com\/markets\/life-sciences\/products\/data-tools. 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