{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T22:13:59Z","timestamp":1769638439222,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,20]],"date-time":"2017-08-20T00:00:00Z","timestamp":1503187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004061","name":"Oesterreichische Nationalbank","doi-asserted-by":"publisher","award":["14621"],"award-info":[{"award-number":["14621"]}],"id":[{"id":"10.13039\/501100004061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p>Patients with primary hyperparathyroidism are at increased risk for high blood pressure, vascular stiffening, and left ventricular hypertrophy, but previous studies have failed to demonstrate the direct associations with circulating parathyroid hormone (<jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>) levels. The authors investigated cross\u2010sectional relationships between <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> and 24\u2010hour pulse wave velocity, nocturnal systolic <jats:styled-content style=\"fixed-case\">blood pressure,<\/jats:styled-content> and left ventricular mass index in <jats:styled-content style=\"fixed-case\">patients with primary hyperparathyroidism<\/jats:styled-content> who were treatment\u2010naive with cinacalcet, renin\u2010angiotensin\u2010aldosterone\u2010system inhibitors, and thiazide or loop diuretics. In 76 patients, mean\u00b1<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> of <jats:styled-content style=\"fixed-case\">pulse wave velocity<\/jats:styled-content>, nocturnal <jats:styled-content style=\"fixed-case\">systolic blood pressure,<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">left ventricular mass index<\/jats:styled-content> values were 9.3\u00b11.8\u00a0m\/s, 116.6\u00b117.0\u00a0mm\u00a0Hg, and 92.8\u00b123.0\u00a0g\/m\u00b2. In multivariate linear regression analyses with adjustment for potentially confounding parameters, <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> was independently associated with nocturnal <jats:styled-content style=\"fixed-case\">systolic blood pressure<\/jats:styled-content> (adjusted \u00df coefficient=.284, <jats:italic>P<\/jats:italic>=.040), mean 24\u2010hour <jats:styled-content style=\"fixed-case\">pulse wave velocity<\/jats:styled-content> (\u00df=.199, <jats:italic>P<\/jats:italic>=.001), and <jats:styled-content style=\"fixed-case\">left ventricular mass index<\/jats:styled-content> (\u00df=.252, <jats:italic>P<\/jats:italic>=.025). <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> may promote vascular and cardiac remodeling in <jats:styled-content style=\"fixed-case\">primary hyperparathyroidism<\/jats:styled-content>. Interventional trials are needed to test the antihypertensive and cardioprotective effects of <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>\u2010inhibitory treatment strategies.<\/jats:p>","DOI":"10.1111\/jch.13064","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T03:12:40Z","timestamp":1503285160000},"page":"1173-1180","source":"Crossref","is-referenced-by-count":17,"title":["Plasma parathyroid hormone and cardiovascular disease in treatment\u2010naive patients with primary hyperparathyroidism: The <scp>EPATH<\/scp> trial"],"prefix":"10.1111","volume":"19","author":[{"given":"Julia","family":"Wetzel","sequence":"first","affiliation":[{"name":"Department of Anesthesiology University Hospital of the RWTH Aachen  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Pilz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Endocrinology and Diabetology Medical University of Graz  Graz Austria"},{"name":"Department of Epidemiology and Biostatistics EMGO Institute for Health and Care Research VU University Medical Centre  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1761-2914","authenticated-orcid":false,"given":"Martin R.","family":"Gr\u00fcbler","sequence":"additional","affiliation":[{"name":"Swiss Cardiovascular Center Bern Department of Cardiology Bern University Hospital  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"Fahrleitner\u2010Pammer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Endocrinology and Diabetology Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans P.","family":"Dimai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Endocrinology and Diabetology Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"von Lewinski","sequence":"additional","affiliation":[{"name":"Department of Cardiology Medical University Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewald","family":"Kolesnik","sequence":"additional","affiliation":[{"name":"Department of Cardiology Medical University Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Perl","sequence":"additional","affiliation":[{"name":"Department of Cardiology Medical University Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Trummer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Endocrinology and Diabetology Medical University of Graz  Graz 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