{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T15:11:20Z","timestamp":1769353880284,"version":"3.49.0"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,24]],"date-time":"2017-09-24T00:00:00Z","timestamp":1506211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007620","name":"Department of Education of Liaoning Province","doi-asserted-by":"publisher","award":["20131015900"],"award-info":[{"award-number":["20131015900"]}],"id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p>This study aimed to investigate whether conventional predisposing factors modify the associations of homocysteine with blood pressure levels and hypertension. A total of 2615 adults were recruited from Liaoning province. An elevated homocysteine level was significantly associated with increased hypertension risk and <jats:styled-content style=\"fixed-case\">blood pressure<\/jats:styled-content> (all <jats:italic>P<\/jats:italic>&lt;.05). Interaction analyses showed that homocysteine acted synergistically with age, overweight\/obesity, dyslipidemia, and family history of hypertension to affect hypertension risk, and the relative excess risk due to interaction was 1.21 (95% confidence interval, 0.07\u20132.35), 0.72 (95% confidence interval, 0.07\u20131.36), 0.45 (95% confidence interval, 0.06\u20130.85), and 1.87 (95% confidence interval, 0.77\u20132.97), respectively. Increases in blood pressure were higher in patients who were overweight\/obese or had a family history of hypertension than in their counterparts (all <jats:italic>P<\/jats:italic><jats:sub>interaction<\/jats:sub> &lt;.05). This study provides some strong evidence for interactions of homocysteine with conventional predisposing factors on hypertension.<\/jats:p>","DOI":"10.1111\/jch.13075","type":"journal-article","created":{"date-parts":[[2017,9,24]],"date-time":"2017-09-24T08:12:49Z","timestamp":1506240769000},"page":"1162-1170","source":"Crossref","is-referenced-by-count":30,"title":["Interactions of homocysteine and conventional predisposing factors on hypertension in Chinese adults"],"prefix":"10.1111","volume":"19","author":[{"given":"Boyi","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment School of Public Health Sun Yat\u2010sen University  Guangzhou China"},{"name":"School of Public Health Research Center of Environment and Non\u2010Communicable Disease China Medical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3570-4484","authenticated-orcid":false,"given":"Shujun","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Public Health Research Center of Environment and Non\u2010Communicable Disease China Medical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueyuan","family":"Zhi","sequence":"additional","affiliation":[{"name":"School of Public Health Research Center of Environment and Non\u2010Communicable Disease China Medical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"He","sequence":"additional","affiliation":[{"name":"Department of Non\u2010Communicable Disease Shenhe Center for Disease Control and Prevention  Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Non\u2010Communicable Disease Shenhe Center for Disease Control and Prevention  Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luyang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Non\u2010Communicable Disease Shenhe Center for Disease Control and Prevention  Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quanmei","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Public Health Research Center of Environment and Non\u2010Communicable Disease China Medical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guifan","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Public Health Research Center of Environment and Non\u2010Communicable Disease China Medical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60655-8"},{"key":"e_1_2_10_3_1","unstructured":"World Health Organization.Global status report on noncommunicable diseases 2010.Geneva Switzerland:World Health Organization.2010. 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