{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T14:47:29Z","timestamp":1744814849953,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T00:00:00Z","timestamp":1515110400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Spanish Health Authority","award":["EC11-426"],"award-info":[{"award-number":["EC11-426"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>Renal denervation and spironolactone have both been proposed for the treatment of resistant hypertension, but their effects on preclinical target organ damage have not been compared. Twenty\u2010four patients with 24\u2010hour systolic blood pressure \u2265140\u00a0mm\u00a0Hg despite receiving three or more full\u2010dose antihypertensive drugs, one a diuretic, were randomized to receive spironolactone or renal denervation. Changes in 24\u2010hour blood pressure, urine albumin excretion, arterial stiffness, carotid intima\u2010media thickness, and left ventricular mass index were evaluated at 6\u00a0months. Mean baseline\u2010adjusted difference between the two groups (spironolactone vs renal denervation) at 6\u00a0months in 24\u2010hour systolic blood pressure was \u221217.9\u00a0mm\u00a0Hg (95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>], \u221230.9 to \u22124.9; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01). Mean baseline\u2010adjusted change in urine albumin excretion was \u221287.2 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, \u2212164.5 to \u22129.9) and \u221223.8 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, \u2212104.5 to 56.9), respectively (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.028). Mean baseline\u2010adjusted variation of 24\u2010hour pulse pressure was \u221213.5 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, \u221218.8 to \u22128.2) and \u22122.1 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, \u22127.9 to 3.7), respectively (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.006). The correlation of change in 24\u2010hour systolic blood pressure with change in log\u2010transformed urine albumin excretion was <jats:italic>r\u00a0<\/jats:italic>=\u00a0.713 (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.001). At 6\u00a0months there was a reduction in albuminuria in patients with resistant hypertension treated with spironolactone as compared with renal denervation.<\/jats:p>","DOI":"10.1111\/jch.13156","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T00:44:45Z","timestamp":1515545085000},"page":"69-75","source":"Crossref","is-referenced-by-count":11,"title":["Organ damage changes in patients with resistant hypertension randomized to renal denervation or spironolactone: The <scp>DENERVHTA<\/scp> (Denervaci\u00f3n en Hipertensi\u00f3n Arterial) study"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5503-545X","authenticated-orcid":false,"given":"Anna","family":"Oliveras","sequence":"first","affiliation":[{"name":"Nephrology Department Hospital del Mar  Barcelona Spain"},{"name":"IMIM (Hospital del Mar Medical Research Institute)  Barcelona Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Armario","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Vascular Risk Area Hospital Mois\u00e9s Broggi Consorci Sanitari Integral University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laia","family":"Sans","sequence":"additional","affiliation":[{"name":"Nephrology Department Hospital del Mar  Barcelona Spain"},{"name":"IMIM (Hospital del Mar Medical Research Institute)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Clar\u00e0","sequence":"additional","affiliation":[{"name":"IMIM (Hospital del Mar Medical Research Institute)  Barcelona Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Vascular Surgery Department Hospital del Mar  Barcelona 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Sierra","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Hospital M\u00fatua Terrassa University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Pascual","sequence":"additional","affiliation":[{"name":"Nephrology Department Hospital del Mar  Barcelona Spain"},{"name":"IMIM (Hospital del Mar Medical Research Institute)  Barcelona Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona  Barcelona 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