{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T13:38:05Z","timestamp":1768829885242,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T00:00:00Z","timestamp":1523664000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>Myeloproliferative neoplasms (<jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content>s) with Janus kinase 2 (<jats:styled-content style=\"fixed-case\">JAK<\/jats:styled-content>2) mutation are associated with a high risk for occlusive vascular diseases. We report 2 cases of renovascular hypertension associated with <jats:styled-content style=\"fixed-case\">JAK<\/jats:styled-content>2 V617F mutation\u2010positive <jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content>s and provide a literature review. In Case 1, a 63\u2010year\u2010old woman had resistant hypertension, massive proteinuria, and erythrocytosis. Evaluations revealed right renal artery stenosis causing renovascular hypertension and polycythemia vera with <jats:styled-content style=\"fixed-case\">JAK<\/jats:styled-content>2 V617F mutation. Renin\u2010angiotensin system inhibitors and subsequent angioplasty controlled the blood pressure and the proteinuria resolved. In Case 2, a 74\u2010year\u2010old woman had resistant hypertension and thrombocytosis. Evaluations confirmed left renal artery stenosis and essential thrombocythemia with <jats:styled-content style=\"fixed-case\">JAK<\/jats:styled-content>2 V617F. Angioplasty cured the hypertension. A literature review of 18 cases revealed the following as the most common characteristics of <jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content>\u2010associated renovascular hypertension: manifests primarily in women; is associated with untreated polycythemia vera and essential thrombocythemia, concomitant leukocytosis, and <jats:styled-content style=\"fixed-case\">JAK<\/jats:styled-content>2 mutation positivity; and is responsive to angioplasty. This report demonstrates that <jats:styled-content style=\"fixed-case\">JAK<\/jats:styled-content>2 mutation\u2010positive <jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content>s are a less common but important underlying cause of adult renovascular hypertension.<\/jats:p>","DOI":"10.1111\/jch.13257","type":"journal-article","created":{"date-parts":[[2018,4,15]],"date-time":"2018-04-15T00:17:37Z","timestamp":1523751457000},"page":"798-804","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Renovascular hypertension associated with <scp>JAK<\/scp>2 V617F positive myeloproliferative neoplasms treated with angioplasty: 2 cases and literature review"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3706-2745","authenticated-orcid":false,"given":"Eikan","family":"Mishima","sequence":"first","affiliation":[{"name":"Division of Nephrology, Endocrinology, and Vascular Medicine 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