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style=\"fixed-case\">PWV<\/jats:styled-content>) indices and ankle\u2010brachial index (<jats:styled-content style=\"fixed-case\">ABI<\/jats:styled-content>) by an automatic device (VP2000, OMRON Health Care Co. 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Multivariate regression models showed independent associations between lower <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>, lower <jats:styled-content style=\"fixed-case\">ABI<\/jats:styled-content> (Coef: 0.42 &amp; 0.41 for right and left), higher hf\u2010<jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content> (Coef: \u221211.4 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: \u221215.4, \u22127.3]) and greater <jats:styled-content style=\"fixed-case\">PAD<\/jats:styled-content> risk (adjusted <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 0.83 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.76, 0.91], all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> set at 77 <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\/min\/1.73m<jats:sup>2<\/jats:sup> was observed to be useful clinical cutoff (c\u2010statistics: 0.67) for identifying <jats:styled-content style=\"fixed-case\">PAD<\/jats:styled-content> (<jats:italic>P<\/jats:italic> for \u0394<jats:styled-content style=\"fixed-case\">AUROC<\/jats:styled-content>: .009; likelihood <jats:italic>X<\/jats:italic><jats:sup><jats:italic>2<\/jats:italic><\/jats:sup>: 93.82 to 137.43, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) when superimposed on clinical risks. This study suggested early renal insufficiency is tightly linked to region\u2010specific vascular stiffness and PAD.<\/jats:p>","DOI":"10.1111\/jch.13297","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T09:50:02Z","timestamp":1526032202000},"page":"1027-1035","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The relationship of renal function to segmental vascular stiffness, ankle\u2010brachial index, and peripheral artery disease"],"prefix":"10.1111","volume":"20","author":[{"given":"Yueh\u2010Hung","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Medicine Mackay Medical College  New Taipei City Taiwan"},{"name":"Division of Cardiology Department of Internal Medicine MacKay Memorial Hospital  Taipei 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