{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T17:58:27Z","timestamp":1772128707133,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T00:00:00Z","timestamp":1531785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23 HL119622\u201001"],"award-info":[{"award-number":["K23 HL119622\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1 TR 001079"],"award-info":[{"award-number":["UL1 TR 001079"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>The American Heart Association defines mood disorders (<jats:styled-content style=\"fixed-case\">MDO<\/jats:styled-content>) as a tier\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> cardiovascular disease risk factor in children. Cross\u2010sectional analysis of overweight\/obese children referred to an obesity hypertension clinic revealed 37% had a <jats:styled-content style=\"fixed-case\">MDO<\/jats:styled-content> (defined by clinical diagnosis or Patient Health Questionnaire\u20109\/\u2010A score \u226510), 55% had confirmed hypertension, and 75% left ventricular hypertrophy (<jats:styled-content style=\"fixed-case\">LVH<\/jats:styled-content>). Children with <jats:styled-content style=\"fixed-case\">MDO<\/jats:styled-content>s were older, had greater measures of adiposity, and had a greater prevalence of hypertension (78%) than those without <jats:styled-content style=\"fixed-case\">MDO<\/jats:styled-content>s (42%; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.04). Hypertensive children were 2.8 times more likely to have a <jats:styled-content style=\"fixed-case\">MDO<\/jats:styled-content> than those without (52% vs 18%; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.02). Multivariable logistic regression revealed a statistically significant independent association of <jats:styled-content style=\"fixed-case\">MDO<\/jats:styled-content>s with hypertension (Odds Ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>] 6.3, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.048), but not <jats:styled-content style=\"fixed-case\">LVH<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">LVMI<\/jats:styled-content>\u00a0\u2265\u00a051\u00a0g\/m<jats:sup>2.7<\/jats:sup>; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.13, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.88). Overall, the prevalence of <jats:styled-content style=\"fixed-case\">MDO<\/jats:styled-content>s in this group of overweight\/obese children with elevated blood pressure was well above national averages, suggesting that at\u2010risk youth, particularly those with confirmed hypertension, should be regularly screened for <jats:styled-content style=\"fixed-case\">MDO<\/jats:styled-content>s.<\/jats:p>","DOI":"10.1111\/jch.13348","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T01:42:22Z","timestamp":1531964542000},"page":"1268-1275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association of mood disorders with cardiovascular disease risk factors in overweight and obese youth with elevated blood pressure"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5526-3543","authenticated-orcid":false,"given":"Leah","family":"Medrano","sequence":"first","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaushalendra","family":"Amatya","sequence":"additional","affiliation":[{"name":"Division of Child and Adolescent Psychiatry Children's National Medical Center Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Vizthum","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Translational Research Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey J.","family":"Fadrowski","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tammy M.","family":"Brady","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000229"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2010.05.017"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3928\/00485713-20120806-09"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2016.00312"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800027-JLR200"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e31815580b4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2015.08.009"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/00048674.2011.570309"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.10.042"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12717"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.8.727"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-013-0782-5"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199806043382302"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.02.044"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.114.2.S2.555"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-1904"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2009.03.003"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-139X(01)00333-0"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199910000-00011"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1497.2006.00409.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200310000-00009"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(03)00608-5"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12357"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291712002991"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-004138"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21023"},{"key":"e_1_2_7_29_1","first-page":"7","article-title":"Abdominal obesity and cardiovascular disease risk factors within body mass index categories","volume":"23","author":"Shields M","year":"2012","journal-title":"Health Rep"},{"key":"e_1_2_7_30_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.4088\/JCP.14m09169","article-title":"Fat distribution and major depressive disorder in late adolescence","volume":"77","author":"Coryell WH","year":"2015","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2008.07.012"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174678"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2007.04.013"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2003.12.030"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2012.05.017"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12966-016-0432-4"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-1878"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eatbeh.2016.03.004"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1089\/chi.2016.0128"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11121-016-0714-8"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.1227"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2012.0095"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e32833df61a"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0b013e32832f2fb1"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2011.01705.x"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2012.02655.x"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2214.2003.00324.x"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-2974"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.160.7.694"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2017.03.020"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.21.2508"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjch.13348","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.13348","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T11:31:30Z","timestamp":1694950290000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.13348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,17]]},"references-count":50,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1111\/jch.13348"],"URL":"https:\/\/doi.org\/10.1111\/jch.13348","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,17]]},"assertion":[{"value":"2018-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}