{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:01:08Z","timestamp":1791925268770,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T00:00:00Z","timestamp":1532649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1K23 HL119622\u201001"],"award-info":[{"award-number":["1K23 HL119622\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>Nonsteroidal anti\u2010inflammatory drugs (<jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s) are used as tocolytics, which are medications that suppress uterine contractions for preterm birth prevention. Their effect on cerebral\/systemic vascular beds poses the question of whether antenatal <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content> exposure is associated with neonatal hypertension. We performed a retrospective case\u2010control study in a tertiary neonatal intensive care unit, including 40 hypertension cases (hospitalized neonates \u2265 35\u00a0weeks with systolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\u00a0&gt;\u00a0100\u00a0mm\u00a0Hg on three consecutive days) compared to 134 controls matched by gestational age at delivery, plurality, and delivery date. Cases and controls were compared by antenatal <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content> exposure, other common tocolytics, and maternal\/neonatal characteristics and complications. Multivariable logistic regression was used to estimate the odds of hypertension among those with prenatal exposure to <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s versus those without exposure. Newborns with hypertension had a lower gestational age at delivery and increased incidence of neonatal complications, including respiratory distress syndrome, bronchopulmonary dysplasia, surfactant administration, longer duration of ventilation, and history of umbilical artery catheterization. Days of indomethacin exposure were positively associated with greater odds of neonatal hypertension (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.17 [1.00 to 1.38], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.055), even after adjustment for other factors associated with neonatal hypertension. Newborns with hypertension were less likely to have been exposed to calcium channel blockers as a tocolytic. The results of our study suggest an association between prenatal exposure to nonsteroidal anti\u2010inflammatory drugs and neonatal hypertension. Furthermore, our data suggest that prenatal calcium channel blocker exposure may protect against the development of neonatal hypertension. Future multicenter studies are needed to understand the risks of tocolytics and subsequent consequences in preterm infants.<\/jats:p>","DOI":"10.1111\/jch.13354","type":"journal-article","created":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T11:40:38Z","timestamp":1532691638000},"page":"1334-1341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Antenatal exposure to nonsteroidal anti\u2010inflammatory drugs and risk of neonatal hypertension"],"prefix":"10.1111","volume":"20","author":[{"given":"Mounira","family":"Habli","sequence":"first","affiliation":[{"name":"Maternal\u2010Fetal Medicine Good Samaritan Hospital  Cincinnati Ohio"},{"name":"Cincinnati Fetal Center  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey C.","family":"Clifford","sequence":"additional","affiliation":[{"name":"Obstetrics\/Gynecology TriHealth Hospitals  Cincinnati Ohio"},{"name":"Obstetrics\/Gynecology The University of Texas Health Science Center at Houston  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammy M.","family":"Brady","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology Johns Hopkins University  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahidee","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Pediatrics Cincinnati Children's Hospital Medical Center  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Eschenbacher","sequence":"additional","affiliation":[{"name":"TriHealth Hatton Research Institute Good Samaritan Hospital  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm","family":"Wu","sequence":"additional","affiliation":[{"name":"University of Cincinnati  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"DeFranco","sequence":"additional","affiliation":[{"name":"Perinatal Institute Cincinnati Children's Hospital Medical Center  Cincinnati Ohio"},{"name":"Maternal\u2010Fetal Medicine University of Cincinnati School of Medicine  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Gresh","sequence":"additional","affiliation":[{"name":"University of Cincinnati  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8482-4802","authenticated-orcid":false,"given":"Beena D.","family":"Kamath\u2010Rayne","sequence":"additional","affiliation":[{"name":"Perinatal Institute Cincinnati Children's Hospital Medical Center  Cincinnati Ohio"},{"name":"Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001265"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867323666160210125920"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e6226"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.04.019"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199311253292202"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.07.051"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90163-9"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-010-1755-z"},{"key":"e_1_2_7_10_1","unstructured":"World Health Organization.Preterm birth.2017.http:\/\/www.who.int\/mediacentre\/factsheets\/fs363\/en\/. 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