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In this study, systolic blood pressure, diastolic blood pressure, pulse pressure (vascular compliance), large artery elasticity, systemic vascular resistance (SVR), total vascular impedance (TVI), and body mass index (BMI) were measured before and after treatment with spironolactone in 10 women with PCOS. Systolic BP, diastolic BP, and BMI were similar prior to treatment and after treatment. Pulse pressure decreased slightly post\u2010treatment compared to pretreatment but not to significance (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.07). The results show that after treatment with spironolactone, there was a statistically significant increase in large artery elasticity (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.047), while there was a statistically significant decrease in SVR and TVI (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0005 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03). This study indicates that treatment with spironolactone improves large artery elasticity and reduces systemic vascular resistance without any change in small artery elasticity.<\/jats:p>","DOI":"10.1111\/jch.13385","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T08:30:37Z","timestamp":1537086637000},"page":"1536-1540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Vascular compliance in women with polycystic ovary syndrome treated with spironolactone"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8042-8001","authenticated-orcid":false,"given":"Ozgul","family":"Muneyyirci\u2010Delale","sequence":"first","affiliation":[{"name":"Division of Reproductive Endocrinology SUNY Downstate Medical Center  Brooklyn NY USA"},{"name":"Department of Obstetrics and Gynecology SUNY Downstate Medical Center  Brooklyn NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherilyne","family":"Co","sequence":"additional","affiliation":[{"name":"SUNY Downstate Medical School College of Medicine  Brooklyn NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathaniel","family":"Winer","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine SUNY Downstate Medical Center  Brooklyn NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,14]]},"reference":[{"issue":"6","key":"e_1_2_7_2_1","first-page":"336","article-title":"Polycystic ovary syndrome: a review of treatment options with a focus on pharmacological approaches","volume":"38","author":"Ndefo UA","year":"2013","journal-title":"P T"},{"key":"e_1_2_7_3_1","volume-title":"Beyond infertility: polycystic ovary syndrome (PCOS)","author":"NIH Department of Health and Human Services","year":"2008"},{"key":"e_1_2_7_4_1","first-page":"1393","volume-title":"Pharmacotherapy: a pathophysiologic approach","author":"Umland EM","year":"2011"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.07.005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:30:1:19"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/NMC.0b013e31824239ce"},{"key":"e_1_2_7_8_1","volume-title":"Health, United States, 2016: with chartbook on long\u2010term trends in health","author":"National Center for Health Statistics","year":"2017"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2724"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmr046"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-003-0069-y"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1559-4564.2007.06454.x"},{"issue":"4","key":"e_1_2_7_13_1","first-page":"611","article-title":"Cardiovascular risk in women with PCOS. 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