{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:23:39Z","timestamp":1789914219201,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:00:00Z","timestamp":1537488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006138","name":"Soci\u00e9t\u00e9 Fran\u00e7aise d\u2019Hypertension Art\u00e9rielle","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006138","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>\n                    Despite the availability of efficient therapies to reduce the risk of cardiovascular complications, poor adherence to antihypertensive (anti\u2010HTN) drugs is frequent, especially during the first year of treatment and among uncontrolled\/resistant hypertensive patients. The aim of the study was to identify factors associated with adherence to anti\u2010HTN treatment and to examine whether they differ across sex. A total of 2743 treated hypertensive participants to the cross\u2010sectional Metascope survey (France, 2015) aged 55\u00a0years or more were included. The authors measured adherence to anti\u2010HTN treatment using the 6\u2010item Girerd compliance test. Variations in adherence were examined using the Rao\u2010Scott statistics and Poisson regression. Overall, 63.6% of participants were adherent to anti\u2010HTN treatment. Adherence was more frequent among women than men (69% vs 58%,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a010\n                    <jats:sup>\u22124<\/jats:sup>\n                    ). For both sexes, level of adherence was positively associated with age (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a010\n                    <jats:sup>\u22124<\/jats:sup>\n                    ), but inversely associated with number of anti\u2010HTN tablets, number of tablets taken for metabolic diseases, history of cardiovascular diseases, number of other chronic diseases (all\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a010\n                    <jats:sup>\u22124<\/jats:sup>\n                    ). The inverse relationship between adherence and the number of anti\u2010HTN tablets significantly differed between sexes (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a010\n                    <jats:sup>\u22124<\/jats:sup>\n                    ): Adherence decreased sharply when taking two or more anti\u2010HTN tablets in men, whereas the decrease in women was only observed when taking three or more anti\u2010HTN tablets. This study suggests that adherence to anti\u2010HTN treatment is higher among women, decreases with the number of tablets prescribed, and differentially so across sex. Reducing the number of tablets for anti\u2010HTN treatment may improve adherence, especially among men and patients with multiple comorbidities.\n                  <\/jats:p>","DOI":"10.1111\/jch.13387","type":"journal-article","created":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T18:39:12Z","timestamp":1537555152000},"page":"1496-1503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Sex differences in adherence to antihypertensive treatment in patients aged above 55: The French League Against Hypertension Survey (FLAHS)"],"prefix":"10.1111","volume":"20","author":[{"given":"Mathilde","family":"Lefort","sequence":"first","affiliation":[{"name":"Univ Rennes, EHESP, REPERES (Recherche en Pharmaco\u2010\u00e9pid\u00e9miologie et Recours aux Soins) \u2013 EA 7449 Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6429-0551","authenticated-orcid":false,"given":"Lola","family":"Neufcourt","sequence":"additional","affiliation":[{"name":"Univ Rennes, EHESP, REPERES (Recherche en Pharmaco\u2010\u00e9pid\u00e9miologie et Recours aux Soins) \u2013 EA 7449 Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Pannier","sequence":"additional","affiliation":[{"name":"Comit\u00e9 Fran\u00e7ais de Lutte Contre l\u2019Hypertension Art\u00e9rielle (CFLHTA) Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Va\u00efsse","sequence":"additional","affiliation":[{"name":"Comit\u00e9 Fran\u00e7ais de Lutte Contre l\u2019Hypertension Art\u00e9rielle (CFLHTA) Paris France"},{"name":"Service de Cardiologie: Rythmologie et HTA Marseille Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Bayat","sequence":"additional","affiliation":[{"name":"Univ Rennes, EHESP, REPERES (Recherche en Pharmaco\u2010\u00e9pid\u00e9miologie et Recours aux Soins) \u2013 EA 7449 Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Grimaud","sequence":"additional","affiliation":[{"name":"Univ Rennes, EHESP, REPERES (Recherche en Pharmaco\u2010\u00e9pid\u00e9miologie et Recours aux Soins) \u2013 EA 7449 Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Girerd","sequence":"additional","affiliation":[{"name":"Comit\u00e9 Fran\u00e7ais de Lutte Contre l\u2019Hypertension Art\u00e9rielle (CFLHTA) Paris France"},{"name":"Sorbonne Universit\u00e9, Assistance Publique des H\u00f4pitaux de Paris, Unit\u00e9 de Pr\u00e9vention Cardio\u2010 Vasculaire. H\u00f4pital de La Piti\u00e9\u2010Salp\u00eatri\u00e8re Paris Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2010.0575"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39553.670231.25"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.022922"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079908X280554"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0b013e3181d567bd"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10198-013-0554-4"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050100"},{"issue":"8","key":"e_1_2_9_9_1","first-page":"839","article-title":"Evaluation de l\u2019observance par l\u2019interrogatoire au cours du suivi des hypertendus dans des 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