{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T10:43:44Z","timestamp":1784717024837,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T00:00:00Z","timestamp":1543968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008792","name":"Novartis Pharma","doi-asserted-by":"publisher","award":["na"],"award-info":[{"award-number":["na"]}],"id":[{"id":"10.13039\/100008792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Though drug adherence is supposed to be low in hypertensive crisis (HTN\u2010C), there are no data available from direct adherence assessments. The aim of the present study was to evaluate adherence to prescribed antihypertensives and potential interactions of concomitant drugs and foods with prescribed antihypertensives in patients with HTN\u2010C by a direct evaluation via biochemical urine analysis. In the present cross\u2010sectional study, 100 patients with HTN\u2010C, admitted to the emergency department (ED), were included. A biochemical urine analysis using gas chromatography\u2010tandem mass spectrometry was performed. Out of 100 patients, 86 received antihypertensives. Urine analyses could be evaluated unambiguously in 62 patients. In 15 of these 62 patients (24%), a nonadherence could be demonstrated, and in 21 patients (34%), a partial nonadherence could be demonstrated. Patients with nonadherence or partial nonadherence showed a longer hypertension history (15[5\u201022] vs 10[3\u201015] years, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04) were prescribed more general medication (number 7.1\u00a0\u00b1\u00a03.4 vs 3.4\u00a0\u00b1\u00a01.8; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) as well as antihypertensive drugs (number 2.8\u00a0\u00b1\u00a01.1 vs 1.5\u00a0\u00b1\u00a00.7, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). A potential BP\u2010raising trigger by medications or food interaction was frequently detectable, predominantly with nonsteroidal anti\u2010inflammatory drugs (NSAIDs; n\u00a0=\u00a038), glucocorticoids (n\u00a0=\u00a08), antidepressants (n\u00a0=\u00a010), and licorice (n\u00a0=\u00a010). Nonadherence and partial nonadherence to prescribed antihypertensives might play a crucial role for the occurrence of HTN\u2010C. However, further case\u2010controlled studies are needed to confirm the present findings. Ingestion of concurrent over\u2010the\u2010counter drugs such as NSAIDs but also prescribed drugs as well as aliments may lead to critical BP elevation. In order to prevent HTN\u2010C, the present findings emphasize the importance for clinicians to pay attention to the issue of adherence and co\u2010medication.<\/jats:p>","DOI":"10.1111\/jch.13448","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T09:31:10Z","timestamp":1544002270000},"page":"55-63","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Direct assessment of adherence and drug interactions in patients with hypertensive crisis\u2014A cross\u2010sectional study in the Emergency Department"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1162-4682","authenticated-orcid":false,"given":"Manuel","family":"Wallbach","sequence":"first","affiliation":[{"name":"Department of Nephrology and Rheumatology University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Lach","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Stock","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Hiller","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirini","family":"Mavropoulou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Gastrointestinal Oncology University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myra\u2010Lynn","family":"Chavanon","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine and Psychotherapy and German Center for Cardiovascular Research (DZHK), Partner site G\u00f6ttingen University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartmud","family":"Neurath","sequence":"additional","affiliation":[{"name":"GIZ\u2010Nord Poisons Center University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Blaschke","sequence":"additional","affiliation":[{"name":"Interdisciplinary Emergency Department University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Lowin","sequence":"additional","affiliation":[{"name":"Department 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