{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:24:55Z","timestamp":1759047895493,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T00:00:00Z","timestamp":1545609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In a pre\u2010specified subgroup analysis of a 12\u2010week randomized multicenter study, we investigated effects of valsartan\/amlodipine 80\/5\u00a0mg single\u2010pill combination (n\u00a0=\u00a075) and nifedipine GITS 30\u00a0mg (n\u00a0=\u00a075) on ambulatory blood pressure (BP) and arterial stiffness assessed by brachial\u2010ankle pulse wave velocity (PWV) in patients with uncontrolled hypertension. At week 12, the between\u2010treatment mean differences in systolic\/diastolic BP were smaller for 24\u2010hour and daytime (\u20132.1\/\u20131.7 and \u22122.0\/\u22121.5\u00a0mm\u00a0Hg, respectively, <jats:italic>P<\/jats:italic>\u00a0\u2265\u00a00.22) but greater (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) for nighttime (\u20134.0\/\u20102.8\u00a0mm\u00a0Hg, <jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.09), especially in sustained uncontrolled hypertension (\u22125.0\/\u22124.1\u00a0mm\u00a0Hg, <jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.04) and non\u2010dippers (\u22126.5\/\u22123.7\u00a0mm\u00a0Hg, <jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.07), in favor of valsartan\/amlodipine. At week 12, PWV was significantly reduced from baseline by valsartan\/amlodipine (n\u00a0=\u00a059, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) but not nifedipine (n\u00a0=\u00a059, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.06). The changes in PWV were significantly associated with that in ambulatory systolic BP and pulse pressure in the nifedipine (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.0008) but not valsartan\/amlodipine group (<jats:italic>P<\/jats:italic>\u00a0\u2265\u00a00.57), with a significant interaction (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.045). The valsartan\/amlodipine combination was more efficacious than nifedipine GITS in lowering nighttime BP in sustained uncontrolled hypertension and non\u2010dippers, and in lowering arterial stiffness independent of BP lowering.<\/jats:p>","DOI":"10.1111\/jch.13457","type":"journal-article","created":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T08:36:12Z","timestamp":1545640572000},"page":"252-261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A randomized multicenter study on ambulatory blood pressure and arterial stiffness in patients treated with valsartan\/amlodipine or nifedipine GITS"],"prefix":"10.1111","volume":"21","author":[{"given":"Shao\u2010Kun","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Hypertension, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi\u2010Fang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hypertension, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Fang","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Hypertension, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang\u2010Sheng","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Hypertension, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hypertension, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8511-1524","authenticated-orcid":false,"given":"Ji\u2010Guang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hypertension, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Ruijin 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