{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T07:17:36Z","timestamp":1781767056311,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T00:00:00Z","timestamp":1553212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Science & Technology Commission of Tongzhou District","award":["KJ2018CX007"],"award-info":[{"award-number":["KJ2018CX007"]}]},{"name":"National Natural Science Funding of China","award":["81470566"],"award-info":[{"award-number":["81470566"]}]},{"name":"National Natural Science Funding of China","award":["81670765"],"award-info":[{"award-number":["81670765"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>Type 2 diabetes mellitus (T2DM) patients are often accompanied with hypertension. However, the association of antihypertensive drugs with \u03b2\u2010cell function has not been well studied. To investigate this question, the authors performed a cross\u2010sectional study involving 882 hypertensive T2DM patients. To assess \u03b2\u2010cell function, patients were given 75g glucose orally and C\u2010peptide levels before and 1, 2, and 3\u00a0hours after glucose intake were measured. Homa\u2010\u03b2 was computed by Homeostasis Model Assessment model to evaluate \u03b2\u2010cell function using fasting C\u2010peptide and glucose levels in the plasma. Multivariable\u2010adjusted analysis was performed to evaluate the association of antihypertensive drugs with C\u2010peptide levels, HbA1c, and Homa\u2010\u03b2. Among 882 hypertensive patients, 547 (62.0%) received antihypertensive treatment. Multivariate\u2010adjusted analysis demonstrated that use of calcium channel blockers (CCBs) was negatively associated with HbA1c levels (CCBs: 0.95 [95% CI: 0.92\u20100.98], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002). Our data further illustrated that the C\u2010peptide levels before and 1, 2, and 3\u00a0hours of OGTT were 1.10\u2010, 1.18\u2010, 1.19\u2010, and 1.15\u2010fold increase in T2DM patients taking CCBs (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.084 for fasting C\u2010peptide levels; <jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.024 for C\u2010peptide levels at 1, 2, and 3\u00a0hours after OGTT) in comparison with non\u2010CCB users. Nevertheless, usage of any other antihypertensive drugs did neither associated with HbA1c nor associated with C\u2010peptide levels (<jats:italic>P<\/jats:italic>\u00a0\u2265\u00a00.11). In conclusion, CCB treatment was negatively associated with HbA1c levels but positively associated with \u03b2\u2010cell function in hypertensive T2DM patients, implying that CCBs could be considered to treat hypertensive T2DM patients with reduced \u03b2\u2010cell function.<\/jats:p>","DOI":"10.1111\/jch.13517","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T08:43:36Z","timestamp":1553244216000},"page":"638-647","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The association of calcium channel blockers with \u03b2\u2010cell function in type 2 diabetic patients: A cross\u2010sectional study"],"prefix":"10.1111","volume":"21","author":[{"given":"Dong","family":"Zhao","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory of Diabetes Prevention and Research, Endocrinology Center Capital Medical University Beijing Luhe hospital Beijing 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