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Orthostatic hypotension is considered a manifestation of dysfunction of the autonomic nervous system, caused or facilitated by several neurological or non\u2010neurological diseases and conditions, while its clinical significance is increasingly recognized as a cause of impairment of quality of life and potentially of worse outcomes. Indeed, OH has been extensively studied and numerous prospective cohort studies support its association with adverse events, including coronary artery disease, heart failure, stroke, cognitive dysfunction, and, most importantly, mortality rates. Specific pharmacological and non\u2010pharmacological interventions have been established for the treatment of OH. However, randomized data evaluating the impact of therapeutic interventions on morbidity and mortality outcomes are lacking. Thus, despite that OH seems to have important prognostic implications indicated by several reported associations with adverse events, it remains unclear whether OH treatment could improve prognosis. In the present review, we discuss the clinical applications associated with \u039f\u0397 by outlining the current perspectives on \u039f\u0397 definition, diagnosis, pathophysiology, prognostic role, and treatment.<\/jats:p>","DOI":"10.1111\/jch.13521","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T04:39:28Z","timestamp":1553229568000},"page":"546-554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Orthostatic hypotension: From pathophysiology to clinical applications and therapeutic considerations"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1645-9716","authenticated-orcid":false,"given":"Nikolaos","family":"Magkas","sequence":"first","affiliation":[{"name":"First Department of Cardiology \u201cHippokration\u201d Hospital, University of Athens, Medical School Athens 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