{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:24:12Z","timestamp":1747185852610,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T00:00:00Z","timestamp":1559952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Poor blood pressure (BP) control contributes to complications in sub\u2010Saharan African (SSA) type 2 diabetic individuals. Experts have advocated the use of combination therapies for effective BP control in these patients. The suggested combinations should include a RAAS antagonist and either a CCB or a thiazide diuretic; however, their efficacy is yet to be established in SSA. We investigated the short\u2010term effects of two combination therapies on BP control in SSA type 2 diabetic individuals. This was a double\u2010blinded randomized controlled trial conducted at the Yaound\u00e9 Central Hospital (Cameroon) from October 2016 to May 2017. We included type 2 diabetic patients, newly diagnosed for hypertension. After baseline assessment and 24\u2010hour ABPM, participants were allocated to receive either a fixed combination of perindopril\u00a0+\u00a0amlodipine or perindopril\u00a0+\u00a0indapamide for 42\u00a0days. Data analyses followed the intention\u2010to\u2010treat principle. We included fifteen participants (8 being females) in each group. Both combinations provided good circadian BP control after 6\u00a0weeks with similar efficacy. Twenty\u2010four\u2010hour SBP dropped from 144 to 145\u00a0mm\u00a0Hg vs 128 to 126\u00a0mm\u00a0Hg with perindopril\u2010amlodipine and perindopril\u2010indapamide, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003 for both groups). Twenty\u2010four\u2010hour DBP dropped from 85 to 78\u00a0mm\u00a0Hg (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.013) vs 89 to 79\u00a0mm\u00a0Hg (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.006) in the same respective groups. No significant adverse effect was reported. A fixed initial combination of perindopril\u2010amlodipine or perindopril\u2010indapamide achieved similar effective BP control after 6\u00a0weeks in SSA type 2 diabetic individuals with newly diagnosed hypertension. Therefore, these combinations can be used interchangeably in this indication.<\/jats:p>","DOI":"10.1111\/jch.13557","type":"journal-article","created":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T08:50:06Z","timestamp":1559983806000},"page":"1002-1008","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Short\u2010term effects of perindopril\u2010amlodipine vs perindopril\u2010indapamide on blood pressure control in sub\u2010Saharan type 2 diabetic individuals newly diagnosed for hypertension: A double\u2010blinded randomized controlled trial"],"prefix":"10.1111","volume":"21","author":[{"given":"Eugene","family":"Sobngwi","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Biomedical Sciences University of Yaound\u00e9 I Yaound\u00e9 Cameroon"},{"name":"National Obesity Center Yaound\u00e9 Central Hospital Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliane","family":"Mfeukeu\u2010Kuate","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biomedical Sciences University of Yaound\u00e9 I Yaound\u00e9 Cameroon"},{"name":"Cardiology Unit Yaound\u00e9 Central Hospital Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merveille","family":"Kouam","sequence":"additional","affiliation":[{"name":"National Obesity Center Yaound\u00e9 Central Hospital Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9390-5260","authenticated-orcid":false,"given":"Aurel T.","family":"Tankeu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biomedical Sciences University of Yaound\u00e9 I Yaound\u00e9 Cameroon"},{"name":"National Obesity Center Yaound\u00e9 Central Hospital Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris N.","family":"Nganou\u2010Gnindjio","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biomedical Sciences University of Yaound\u00e9 I Yaound\u00e9 Cameroon"},{"name":"Cardiology Unit Yaound\u00e9 Central Hospital Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ba","family":"Hamadou","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biomedical Sciences University of Yaound\u00e9 I Yaound\u00e9 Cameroon"},{"name":"Cardiology Unit Yaound\u00e9 Central Hospital Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martine","family":"Etoa","sequence":"additional","affiliation":[{"name":"National Obesity Center Yaound\u00e9 Central Hospital Yaound\u00e9 Cameroon"},{"name":"Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliane","family":"Ngassam","sequence":"additional","affiliation":[{"name":"National Obesity Center Yaound\u00e9 Central Hospital Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariane","family":"Nkamgna","sequence":"additional","affiliation":[{"name":"National Obesity Center Yaound\u00e9 Central Hospital Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mesmin Y.","family":"Dehayem","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biomedical Sciences University of Yaound\u00e9 I Yaound\u00e9 Cameroon"},{"name":"National Obesity Center Yaound\u00e9 Central Hospital Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois F.","family":"Kaze","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biomedical Sciences University of Yaound\u00e9 I Yaound\u00e9 Cameroon"},{"name":"University Teaching Hospital of Yaound\u00e9 Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5183-131X","authenticated-orcid":false,"given":"Andre P.","family":"Kengne","sequence":"additional","affiliation":[{"name":"Non\u2010Communicable Diseases Unit South African Medical Research Council Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean C.","family":"Mbanya","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biomedical Sciences University of Yaound\u00e9 I Yaound\u00e9 Cameroon"},{"name":"National Obesity Center Yaound\u00e9 Central Hospital Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci17-0026"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2013.09.005"},{"key":"e_1_2_10_4_1","unstructured":"User S. 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