{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:56:44Z","timestamp":1791475004347,"version":"4.3.4"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T00:00:00Z","timestamp":1559779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009142","name":"Cancer Care Ontario","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009142","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007693","name":"King Chulalongkorn Memorial Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Renin\u2010angiotensin\u2010aldosterone system inhibitors (RAASi) are recommended for chronic kidney disease (CKD) patients. In this study, we describe RAASi prescription patterns in the Chronic Kidney Disease Outcomes and Practice Patterns Study (CKDopps) in Brazil, Germany, France, and the United States (US). 5870 patients (mean age 66\u201072\u00a0years; congestive heart failure [CHF] in 11%\u201019%; diabetes in 43%\u201054%; serum potassium \u22655 in 20%\u201035%) were included. RAASi prescription was more common in Germany (80%) and France (77%) than Brazil (66%) and the United States (52%), where the prevalence of prescription decreases particularly in patients with CKD stage 5. In the multivariable regression model, RAASi prescription was least common in the United States and more common in patients who were younger, had diabetes, hypertension, or less advanced CKD. In conclusion, RAASi prescription patterns vary by country, and by demographic and clinical characteristics. RAASi appear to be underused, even among patients with strong class\u2010specific recommendations. Although the reasons for this variation could not be fully identified in this cross\u2010sectional observation, our data indicate that the risk of hyperkalemia may contribute to the underuse of this class of agents in moderate to advanced CKD.<\/jats:p>","DOI":"10.1111\/jch.13563","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T07:20:37Z","timestamp":1559805637000},"page":"991-1001","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Prescription of renin\u2010angiotensin\u2010aldosterone system inhibitors (RAASi) and its determinants in patients with advanced CKD under nephrologist care"],"prefix":"10.1111","volume":"21","author":[{"given":"Roberto","family":"Pecoits\u2010Filho","sequence":"first","affiliation":[{"name":"School of Medicine Pontificia Universidade Catolica do Parana Curitiba Brazil"},{"name":"Arbor Research Collaborative for Health Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Fliser","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV Saarland University Medical Center Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Tu","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarcy","family":"Zee","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Bieber","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M. Y.","family":"Wong","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health Ann Arbor Michigan"},{"name":"Department of Medicine University of British Columbia Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Port","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health Ann Arbor Michigan"},{"name":"Department of Internal Medicine, Michigan Medicine, and Department of Epidemiology, School of Public Health University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Combe","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie Transplantation Dialyse Centre Hospitalier Universitaire de Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio A.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina da Bahia School of Medicine Universidade Federal da Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Reichel","sequence":"additional","affiliation":[{"name":"Nephrological Center Villingen\u2010Schwenningen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiei","family":"Narita","sequence":"additional","affiliation":[{"name":"Division of Clinical Nephrology and Rheumatology Niigata University Graduate School of Medical and Dental Science Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedicte","family":"Stengel","sequence":"additional","affiliation":[{"name":"CESP, Center for Research in Epidemiology and Population Health University Paris\u2010Saclay, University Paris\u2010Sud, UVSQ Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce M.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziad","family":"Massy","sequence":"additional","affiliation":[{"name":"CESP, Center for Research in Epidemiology and Population Health University Paris\u2010Saclay, University Paris\u2010Sud, UVSQ Villejuif France"},{"name":"Division of Nephrology Ambroise Par\u00e9 University Hospital, APHP Boulogne Billancourt\/Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"CKDopps Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,6]]},"reference":[{"issue":"5","key":"e_1_2_8_2_1","first-page":"337","article-title":"Clinical practice guideline for the management of blood pressure in chronic kidney disease","volume":"2","author":"Kidney Disease: Improving Global Outcomes (KDIGO) Blood Pressure Workgroup","year":"2012","journal-title":"Kidney Int"},{"key":"e_1_2_8_3_1","unstructured":"SkolnikN JohnsonEL.Clinical guidelines: ADA 2017 standards of medical care in diabetes. 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