{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:38:34Z","timestamp":1791923914267,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T00:00:00Z","timestamp":1560297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with primary aldosteronism induced hypertension are more likely to experience cardiovascular events compared to patients with essential hypertension. Primary aldosteronism may therefore have distinct adverse effects on cardiovascular structure and function, independent of hypertension. However, current data on such effects of primary aldosteronism are conflicting. The aim of the present study was to investigate the influence of primary aldosteronism on vascular structure and endothelial function, using intima\u2010media thickness as a vascular remodeling index and flow\u2010mediated dilation as a functional parameter. In total, 70 participants were recruited from patients with resistant hypertension. Twenty\u2010nine patients diagnosed with primary aldosteronism and 41 patients with essential hypertension were prospectively enrolled. Primary aldosteronism was due to aldosterone\u2010producing adenoma in 10 cases and due to idiopathic adrenal hyperplasia in 19 cases. All patients underwent ultrasound of the common carotid intima\u2010media thickness and flow\u2010mediated dilation of the brachial artery. Primary aldosteronism patients had significantly lower flow\u2010mediated dilation (3.3 [2.4\u20107.4] % vs 14.7 [10.3\u201019.9] %, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) and significantly higher carotid intima\u2010media thickness (0.9 [0.7\u20101.0]\u00a0mm vs 0.8 [0.6\u20100.9]\u00a0mm, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) compared to patients with essential hypertension. These differences remained significant after adjusting for age, sex, diabetes mellitus, 24\u2010hours systolic blood pressure, and smoking (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). No differences in either outcome were observed between the adenoma and adrenal hyperplasia groups (both <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). Hypertensive patients with hyperaldosteronism appear to exhibit deteriorative effects on both vascular structure and function, independent of hypertension.<\/jats:p>","DOI":"10.1111\/jch.13585","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T09:34:19Z","timestamp":1560332059000},"page":"932-941","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Hypertension with primary aldosteronism is associated with increased carotid intima\u2010media thickness and endothelial dysfunction"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8104-3296","authenticated-orcid":false,"given":"Ahmet","family":"Demirkiran","sequence":"first","affiliation":[{"name":"Department of Cardiology, Istanbul Faculty of Medicine Istanbul University Istanbul Turkey"},{"name":"Department of Cardiology Amsterdam University Medical Center \u2010 Vrije Universiteit Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk","family":"Everaars","sequence":"additional","affiliation":[{"name":"Department of Cardiology Amsterdam University Medical Center \u2010 Vrije Universiteit Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Elitok","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Istanbul Faculty of Medicine Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"van de Ven","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Amsterdam University Medical Center \u2010 Vrije Universiteit Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvo M.","family":"Smulders","sequence":"additional","affiliation":[{"name":"Division of Vascular Medicine, Department of Internal Medicine Amsterdam University Medical Center \u2010 Vrije Universiteit Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen M.","family":"Dreijerink","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine Amsterdam University Medical Center \u2010 Vrije Universiteit Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Refik","family":"Tanakol","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, Istanbul Faculty of Medicine Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Ozcan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Istanbul Faculty of Medicine Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.059"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.197111"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.01.015"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0681"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000123572.45556.a5"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0101"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00322-2"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.74.6.1399"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3281268532"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32831286fd"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000464"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0922-4106(95)90018-7"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)93147-F"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(96)90311-7"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00189-7"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000129307.26791.8E"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K09E-014"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.088955"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.05001"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001554"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.189141"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-4061"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.58.6.1072"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343145"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01746-6"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/174182670100800512"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01060"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000230444.01215.6a"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2116"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.27.5.1039"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-014-1658-0"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001042"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30367-4"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2019.01.008"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.09294"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18040848"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.9.1297"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.22.1.111"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ15-0362"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.12.003"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000226054.53527.bb"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0864"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000089507.19675.F9"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.09.008"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1149"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjch.13585","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.13585","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jch.13585","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.13585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T13:22:58Z","timestamp":1694265778000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.13585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,12]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1111\/jch.13585"],"URL":"https:\/\/doi.org\/10.1111\/jch.13585","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,12]]},"assertion":[{"value":"2019-01-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}